{"id":"W3087450283","doi":"10.1139/cjpp-2019-0684","title":"BW373U86 upregulates autophagy by inhibiting the PI3K/Akt pathway and regulating the mTOR pathway to protect cardiomyocytes from hypoxia–reoxygenation injury","year":2020,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PI3K/AKT/mTOR pathway; Autophagy; Protein kinase B; Viability assay; Chemistry; LY294002; Cell biology; Myocyte; Downregulation and upregulation; Pharmacology; Molecular biology; Signal transduction; Biology; Apoptosis; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001321827,0.0006103247,0.0006345057,0.0002966209,0.0002697753,0.0001721815,0.0002366222,0.0003006138,0.001345821],"category_scores_gemma":[0.00007657996,0.0001765858,0.0004291154,0.000217957,0.0002687943,0.0002233689,0.0001774068,0.0009138951,0.0003336616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001946792,"about_ca_system_score_gemma":0.0003889856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008205003,"about_ca_topic_score_gemma":0.001752845,"domain_scores_codex":[0.9998703,0.00001528474,0.00001364899,0.00001840786,0.00002674432,0.00005556381],"domain_scores_gemma":[0.9999459,0.000003646292,0.00001472107,0.000005150999,0.000006465558,0.00002425064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009600379,0.0002512801,0.0002593813,0.0001297329,0.00002437892,0.00008106368,0.00001830461,0.0001494878,0.9945201,0.0001076436,0.0001669977,0.003331518],"study_design_scores_gemma":[0.0002989991,0.00396042,0.01377134,0.00003253691,0.000123849,0.0003188501,0.00008288262,0.001460271,0.9770758,0.0001075299,0.002752482,0.00001506859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937297,0.003451859,0.001031176,0.0001895721,0.00006369556,0.00003543995,0.0002965526,0.00009742739,0.001104593],"genre_scores_gemma":[0.994822,0.002266765,0.001092392,0.0001241265,0.00002437214,0.00005360247,0.0003396761,0.00001382767,0.001263137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001345821,"threshold_uncertainty_score":0.004502177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307052411073684,"score_gpt":0.2489847847171505,"score_spread":0.2359142606064137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}