{"id":"W3087452454","doi":"10.1242/dmm.045369","title":"A novel mouse model of Duchenne muscular dystrophy carrying a multi-exonic <i>Dmd</i> deletion exhibits progressive muscular dystrophy and early-onset cardiomyopathy","year":2020,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Duchenne muscular dystrophy; Dystrophin; Muscular dystrophy; Cardiomyopathy; Medicine; Wasting; Myopathy; Skeletal muscle; Mutation; mdx mouse; Hypertrophic cardiomyopathy; Bioinformatics; Internal medicine; Cardiology; Heart failure; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003855724,0.001110387,0.0004643934,0.001319747,0.0005096063,0.0004120311,0.0007478224,0.001293494,0.004823633],"category_scores_gemma":[0.0001169654,0.0004507964,0.0005260712,0.0003630783,0.0006609424,0.0004486377,0.0003952129,0.001286446,0.001371575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004481855,"about_ca_system_score_gemma":0.0002691757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008006941,"about_ca_topic_score_gemma":0.001233616,"domain_scores_codex":[0.9995435,0.00006283304,0.0000836942,0.0001471745,0.00009038814,0.00007235162],"domain_scores_gemma":[0.9996717,0.00004520847,0.0001061175,0.00003425743,0.00003090123,0.0001119353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001273786,0.0001466818,0.0001707789,0.00004964218,0.000009846466,0.0002652262,0.0000315652,0.00007256788,0.9973958,0.0005193282,0.0001695197,0.00104166],"study_design_scores_gemma":[0.0002517129,0.001832736,0.00583372,0.00009434192,0.0001272768,0.004387632,0.0001355554,0.001921609,0.9667504,0.0004301668,0.01819851,0.00003634774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617245,0.002013069,0.02132979,0.000929013,0.0003709416,0.0003427066,0.004628975,0.0009510308,0.007709946],"genre_scores_gemma":[0.9287662,0.002343046,0.02489226,0.0005417333,0.00008085721,0.0007096165,0.005125546,0.0002832813,0.03725745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004823633,"threshold_uncertainty_score":0.01613665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02101459445363573,"score_gpt":0.2216454542991473,"score_spread":0.2006308598455115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}