{"id":"W3087452454","doi":"10.1242/dmm.045369","title":"A novel mouse model of Duchenne muscular dystrophy carrying a multi-exonic <i>Dmd</i> deletion exhibits progressive muscular dystrophy and early-onset cardiomyopathy","year":2020,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Duchenne muscular dystrophy; Dystrophin; Muscular dystrophy; Cardiomyopathy; Medicine; Wasting; Myopathy; Skeletal muscle; Mutation; mdx mouse; Hypertrophic cardiomyopathy; Bioinformatics; Internal medicine; Cardiology; Heart failure; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001329999,0.0004408417,0.0004765728,0.00007049811,0.0001719283,0.00003218279,0.0002822741,0.000246016,0.000003934347],"category_scores_gemma":[0.00007228147,0.0004490576,0.0003861818,0.0001351277,0.0001637267,0.00003455542,0.0002938744,0.0001819096,0.000002207462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001783618,"about_ca_system_score_gemma":0.0001771103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004412263,"about_ca_topic_score_gemma":0.000002594816,"domain_scores_codex":[0.997711,0.0001154586,0.0003972873,0.0009765446,0.0003053824,0.0004943287],"domain_scores_gemma":[0.9984701,0.00000768013,0.0002099197,0.0005587598,0.0002235787,0.00053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008782241,0.0002609004,0.00007693309,0.0002248647,0.0002060093,0.00001513131,0.0003257131,0.07559099,0.9213967,0.0007416717,0.00001302076,0.0002698759],"study_design_scores_gemma":[0.007258331,0.001297245,0.0005427658,0.0001152303,0.0007470577,0.00001156642,0.0003569339,0.7019864,0.2809283,0.00528878,0.00003069626,0.001436637],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6419893,0.001295607,0.3557039,0.00007046561,0.00003160985,0.0005088868,0.0003587734,0.00003569688,0.00000575109],"genre_scores_gemma":[0.9886585,0.0001473707,0.01008828,0.0004021173,0.00007436157,0.0002386099,0.000300223,0.00007736083,0.00001318305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6404684,"threshold_uncertainty_score":0.9997961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02101459445363573,"score_gpt":0.2216454542991473,"score_spread":0.2006308598455115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}