{"id":"W3087527679","doi":"10.1093/infdis/jiaa599","title":"Occurrence of Accelerated Epigenetic Aging and Methylation Disruptions in Human Immunodeficiency Virus Infection Before Antiretroviral Therapy","year":2020,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; National Institute for Health and Care Research; Canadian Institutes of Health Research; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; National Heart, Lung, and Blood Institute","keywords":"DNA methylation; Epigenetics; Methylation; Immunology; Viral load; dNaM; Antiretroviral therapy; Medicine; Human immunodeficiency virus (HIV); Biology; Oncology; Internal medicine; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004074884,0.00009050623,0.0001855324,0.0002557595,0.000171637,0.0002723423,0.0001733804,0.00022564,0.001299861],"category_scores_gemma":[0.001389498,0.0001027098,0.0001334969,0.0003118056,0.0001379536,0.0001355199,0.0001816509,0.0002180041,0.00008249543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001641034,"about_ca_system_score_gemma":0.0001141274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001137335,"about_ca_topic_score_gemma":0.001512642,"domain_scores_codex":[0.9997755,0.00006072149,0.00001426185,0.00008449679,0.0000364254,0.00002856986],"domain_scores_gemma":[0.9994097,0.0001881121,0.0002702493,0.0000472374,0.00004235691,0.00004234971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001151297,0.00003363532,0.9685814,0.00005113389,0.0001595169,0.0001833412,0.0001820729,0.000293376,0.01379225,0.0001067685,0.000153419,0.0153118],"study_design_scores_gemma":[0.000007896149,0.0001827629,0.9963225,0.000006469355,0.00004892646,0.0002712239,0.00006418818,0.0007359438,0.00194579,0.0001143037,0.0002967946,0.000003296505],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985225,0.0004163965,0.0005103171,0.00001832619,0.000003685898,0.000005597269,0.0002567081,0.000008041196,0.0002584588],"genre_scores_gemma":[0.9995282,0.00004756502,0.0001874828,0.0000108456,0.000002800969,0.000005454831,0.0001198795,0.000001684976,0.00009607088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299861,"threshold_uncertainty_score":0.004348457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02230499837356903,"score_gpt":0.3005991138018338,"score_spread":0.2782941154282648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}