{"id":"W3087534897","doi":"10.1016/j.drudis.2020.09.013","title":"Taming the cytokine storm: repurposing montelukast for the attenuation and prophylaxis of severe COVID-19 symptoms","year":2020,"lang":"en","type":"article","venue":"Drug Discovery Today","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Research Manitoba","keywords":"Montelukast; Cytokine storm; Proinflammatory cytokine; Cytokine; Medicine; Immunology; Cytokine release syndrome; Repurposing; Immune system; Drug repositioning; Inflammation; Asthma; Coronavirus disease 2019 (COVID-19); Pharmacology; Drug; Immunotherapy; Internal medicine; Biology; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002584439,0.000344769,0.0006392316,0.0002784825,0.0002654575,0.0009032833,0.0002630742,0.0006293047,0.002151049],"category_scores_gemma":[0.0003952926,0.000115542,0.0004272415,0.0001444739,0.0004966477,0.0005902489,0.0003588779,0.001608078,0.0006707435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002763094,"about_ca_system_score_gemma":0.0004527539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003525722,"about_ca_topic_score_gemma":0.0009412519,"domain_scores_codex":[0.9998864,0.00002005387,0.00001312785,0.00001356638,0.00002509597,0.00004166214],"domain_scores_gemma":[0.9999154,0.00001537819,0.00002035923,0.00000713622,0.00001024854,0.00003149789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.01208952,0.001385435,0.003897733,0.001404813,0.0002531903,0.004663203,0.0002536193,0.001231251,0.4436888,0.01091296,0.01282053,0.5073988],"study_design_scores_gemma":[0.01108987,0.04314792,0.03814004,0.001609598,0.001205643,0.03730029,0.001058013,0.008649834,0.4619541,0.0242051,0.3712461,0.000393504],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7403753,0.2119124,0.00893653,0.01839854,0.00262464,0.0004016563,0.0006003279,0.0006447597,0.01610577],"genre_scores_gemma":[0.9323058,0.05478106,0.004523071,0.002961854,0.000664383,0.00008824805,0.0003089745,0.00003174809,0.004334857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002151049,"threshold_uncertainty_score":0.00719595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209788668124672,"score_gpt":0.240462273466357,"score_spread":0.2283643867851103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}