{"id":"W3087537212","doi":"10.1101/2020.09.19.303826","title":"Msp1/ATAD1 restores mitochondrial function in Zellweger Spectrum Disease","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Huntsman Cancer Institute; Howard Hughes Medical Institute; Nora Eccles Treadwell Foundation; Deutsche Forschungsgemeinschaft; Global Foundation for Peroxisomal Disorders; Bundesministerium für Bildung und Forschung; University of Utah","keywords":"Peroxisome; Biology; Biogenesis; Mitochondrion; Mitochondrial biogenesis; Cell biology; Function (biology); Zellweger syndrome; Phenotype; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002173493,0.0005159731,0.0004614626,0.0005620752,0.0002399082,0.0003005456,0.0002489983,0.000642225,0.002140214],"category_scores_gemma":[0.0001749412,0.0001292131,0.0002722636,0.0002115749,0.0003490527,0.0001190776,0.0003672824,0.0005990295,0.0005525721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002793861,"about_ca_system_score_gemma":0.0001856779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006572855,"about_ca_topic_score_gemma":0.0006701764,"domain_scores_codex":[0.9998757,0.00002221735,0.00002407302,0.00002345749,0.00003809684,0.00001644498],"domain_scores_gemma":[0.9998533,0.00003068809,0.00002821302,0.00001506452,0.00001110699,0.00006162925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002889661,0.00009483372,0.0003955132,0.00004796223,0.00001749693,0.0005660278,0.00002534876,0.000186177,0.9943553,0.0002308451,0.0002574587,0.003534096],"study_design_scores_gemma":[0.0003497383,0.001688842,0.01406301,0.00003301508,0.00006649517,0.004430541,0.000124127,0.004569003,0.9606735,0.0006336781,0.0133405,0.00002755343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993654,0.001025857,0.002729862,0.0003111757,0.00009063574,0.0000293375,0.0007774441,0.0002850654,0.001096583],"genre_scores_gemma":[0.9950224,0.0005454453,0.001551154,0.00008250581,0.00002006475,0.00002095201,0.000802907,0.00005396923,0.001900582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002140214,"threshold_uncertainty_score":0.00715977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112837390089624,"score_gpt":0.2155361867864346,"score_spread":0.2044078128855384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}