{"id":"W3087595653","doi":"10.3899/jrheum.200460","title":"Pegloticase in Combination With Methotrexate in Patients With Uncontrolled Gout: A Multicenter, Open-label Study (MIRROR)","year":2020,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon Therapeutics; Celgene; Gilead Sciences; Sanofi; Eli Lilly and Company; Bristol-Myers Squibb; GlaxoSmithKline; Amgen","keywords":"Medicine; Gout; Discontinuation; Internal medicine; Methotrexate; Randomized controlled trial; Open label; Clinical trial; Population; Surgery","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003116226,0.0009563773,0.001642566,0.0003354075,0.0004697937,0.0008963759,0.0005621851,0.0009484564,0.002078953],"category_scores_gemma":[0.001627999,0.0004452265,0.001124928,0.0004175165,0.0007645739,0.0008413029,0.0004108329,0.001497968,0.0004379287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005328168,"about_ca_system_score_gemma":0.001038718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005291757,"about_ca_topic_score_gemma":0.001121798,"domain_scores_codex":[0.9988425,0.0007100292,0.00008316577,0.0001598932,0.0001064763,0.00009805473],"domain_scores_gemma":[0.9987093,0.0001933452,0.0004845023,0.0001578965,0.00009284858,0.0003620042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8417944,0.05340929,0.02523115,0.0007368347,0.001691746,0.0002106344,0.0003549467,0.0003924777,0.02172181,0.0001156749,0.0009802333,0.05336078],"study_design_scores_gemma":[0.5041921,0.4552985,0.03614544,0.00004445351,0.0007872581,0.0002265782,0.00008517417,0.0004671842,0.001326752,0.00006579611,0.001334279,0.00002657858],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969067,0.001227348,0.0001996131,0.0001361877,0.00003527678,0.0008881988,0.000184857,0.00002268237,0.0003992078],"genre_scores_gemma":[0.9957374,0.0007006043,0.000909607,0.0003474987,0.0002787016,0.001111397,0.0004184222,0.000007769321,0.0004885664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003116226,"threshold_uncertainty_score":0.01648033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02704962424509801,"score_gpt":0.2946405225355755,"score_spread":0.2675908982904775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}