{"id":"W3087608513","doi":"10.1101/2020.09.21.305904","title":"Independent recruitment of PRC1 and PRC2 by human XIST","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"XIST; Biology; X-inactivation; Genetics; Chromatin; PRC2; Heterochromatin; Euchromatin; Dosage compensation; X chromosome; Computational biology; Gene; EZH2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829239,0.0002029028,0.0001399157,0.00009659634,0.0001124276,0.000288423,0.0001540496,0.0001061607,0.001786229],"category_scores_gemma":[0.0001633195,0.0001641599,0.0002192812,0.00008450202,0.0001903857,0.0001335817,0.0003214231,0.0003778781,0.0005768814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349727,"about_ca_system_score_gemma":0.0002412344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005496282,"about_ca_topic_score_gemma":0.001224245,"domain_scores_codex":[0.9998215,0.00002056414,0.00001581051,0.0000512611,0.00006691735,0.00002395675],"domain_scores_gemma":[0.9998856,0.00002516219,0.00002656218,0.0000238344,0.00001526243,0.00002357169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004166256,0.000003643723,0.0003701941,0.00002470653,0.000005227707,0.00003037498,0.00001073045,0.00005593835,0.99837,0.0001542408,0.00003870201,0.0008945366],"study_design_scores_gemma":[0.00001395441,0.00007042526,0.008471321,0.000005213736,0.00001142117,0.0003862577,0.00001438499,0.001106822,0.9844921,0.0000646666,0.005359025,0.000004485846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808307,0.002539226,0.01199142,0.0001321483,0.00003020317,0.00003877401,0.0007271851,0.0001587488,0.003551557],"genre_scores_gemma":[0.9881493,0.0004362201,0.003895632,0.00005033455,0.000007909735,0.0000323571,0.001314685,0.00002937025,0.00608431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001786229,"threshold_uncertainty_score":0.005975544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01999046416442683,"score_gpt":0.2774833767229077,"score_spread":0.2574929125584808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}