{"id":"W3087658477","doi":"10.1371/journal.ppat.1008803","title":"Closely related reovirus lab strains induce opposite expression of RIG-I/IFN-dependent versus -independent host genes, via mechanisms of slow replication versus polymorphisms in dsRNA binding σ3 respectively","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Li Ka Shing Institute of Virology, University of Alberta; University of Alberta; Canadian Institutes of Health Research; Alberta Cancer Foundation; Cancer Research Society; Canada Research Chairs; University of Manitoba; University of Pittsburgh; Alberta Health Services","keywords":"Biology; Oncolytic virus; Viral replication; IRF3; Interferon; Gene; Gene silencing; Virology; Transcription (linguistics); Gene expression; Molecular biology; Virus; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006073379,0.0003260335,0.0004163371,0.0002394405,0.00009911219,0.00001816865,0.000586999,0.0004231324,0.00005858444],"category_scores_gemma":[0.0003033955,0.0003463013,0.0001725062,0.0005507256,0.00009452129,0.00001913645,0.0003277916,0.0003665261,0.00002167814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001513086,"about_ca_system_score_gemma":0.0002688471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005952964,"about_ca_topic_score_gemma":0.0001138456,"domain_scores_codex":[0.9966442,0.0004021595,0.0007038151,0.001016617,0.0007517484,0.0004814728],"domain_scores_gemma":[0.9980498,0.00005607557,0.0004455772,0.0009785861,0.0002370171,0.0002329571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01188432,0.0003094756,0.0003014416,0.00003455216,0.0001758827,0.00004244901,0.0004256139,0.0001088934,0.9847744,0.00006151332,0.00001590481,0.001865562],"study_design_scores_gemma":[0.004634277,0.004364402,0.001552139,0.00005415396,0.00005994201,0.000004504909,0.0002664791,0.0001902675,0.9884748,0.00006089899,0.00002068503,0.000317412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970719,0.0006195063,0.000526531,0.0001817124,0.0001587288,0.0007224443,0.0003832387,0.00003297375,0.0003029551],"genre_scores_gemma":[0.9980916,0.0003591366,0.0009983124,0.00003830126,0.0000874213,0.00005762668,0.0002241159,0.00007952777,0.0000639249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007250042,"threshold_uncertainty_score":0.9998989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04586088519818581,"score_gpt":0.2901574689425248,"score_spread":0.2442965837443389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}