{"id":"W3087658477","doi":"10.1371/journal.ppat.1008803","title":"Closely related reovirus lab strains induce opposite expression of RIG-I/IFN-dependent versus -independent host genes, via mechanisms of slow replication versus polymorphisms in dsRNA binding σ3 respectively","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Li Ka Shing Institute of Virology, University of Alberta; University of Alberta; Canadian Institutes of Health Research; Alberta Cancer Foundation; Cancer Research Society; Canada Research Chairs; University of Manitoba; University of Pittsburgh; Alberta Health Services","keywords":"Biology; Oncolytic virus; Viral replication; IRF3; Interferon; Gene; Gene silencing; Virology; Transcription (linguistics); Gene expression; Molecular biology; Virus; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002540345,0.000470828,0.0002443162,0.0003256584,0.000145992,0.0003772287,0.0002500101,0.0004048775,0.001184341],"category_scores_gemma":[0.0002287283,0.0001321528,0.0005857869,0.0002038378,0.0002573087,0.0001983447,0.0002780177,0.001062387,0.0003378913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003363632,"about_ca_system_score_gemma":0.0001511258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004341756,"about_ca_topic_score_gemma":0.0005780344,"domain_scores_codex":[0.9996448,0.00006407348,0.00005391495,0.0001001688,0.00006744757,0.00006966833],"domain_scores_gemma":[0.9997317,0.00004574617,0.00009895685,0.00005825162,0.00002231147,0.0000431244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001658908,0.00006411319,0.0003130356,0.00001950135,0.000007446014,0.00002285678,0.00001291245,0.00002931643,0.9986193,0.00006846509,0.00002120804,0.0006558945],"study_design_scores_gemma":[0.0000249105,0.001223501,0.004116654,0.000004048024,0.00002223434,0.0004176701,0.00003594098,0.0002807062,0.9928148,0.00005500314,0.0009967235,0.000007819651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954177,0.0004642732,0.002644064,0.00005054137,0.0000333572,0.00006183022,0.0004690887,0.00006012977,0.0007991219],"genre_scores_gemma":[0.990142,0.0003144852,0.005850041,0.00009508064,0.0000128587,0.0001415688,0.001481421,0.00005703491,0.001905574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001184341,"threshold_uncertainty_score":0.00396204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04586088519818581,"score_gpt":0.2901574689425248,"score_spread":0.2442965837443389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}