{"id":"W3087697977","doi":"10.1016/s1470-2045(20)30494-0","title":"Adjuvant nivolumab versus ipilimumab in resected stage IIIB–C and stage IV melanoma (CheckMate 238): 4-year results from a multicentre, double-blind, randomised, controlled, phase 3 trial","year":2020,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":525,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Bristol-Myers Squibb","keywords":"Ipilimumab; Medicine; Nivolumab; Clinical endpoint; Internal medicine; Population; Clinical trial; Adjuvant; Stage (stratigraphy); Randomized controlled trial; Surgery; Phases of clinical research; Adverse effect; Melanoma; Cancer; Oncology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001454505,0.0003240505,0.0017573,0.0001035677,0.0001172192,0.00004429867,0.0003035892,0.0002883986,0.0004904519],"category_scores_gemma":[0.0007784432,0.0002192,0.0002062331,0.0003289657,0.0002870365,0.00009034324,0.0001106468,0.0006441646,0.0000329226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873342,"about_ca_system_score_gemma":0.000431217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001848644,"about_ca_topic_score_gemma":0.002282018,"domain_scores_codex":[0.9967379,0.0007427252,0.0009948567,0.0005995172,0.0003234002,0.000601591],"domain_scores_gemma":[0.9969707,0.001691756,0.0004746492,0.0005649031,0.00008609117,0.0002118631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9774385,0.0005365125,0.00006915225,0.00004279835,0.0007395439,0.0003379725,0.003332087,0.000008632028,0.01092205,0.00002749023,0.002585358,0.00395987],"study_design_scores_gemma":[0.9415421,0.00627738,0.0002562398,0.00005466671,0.0003034809,0.000004940588,0.001601636,0.001934265,0.001129643,0.000006800976,0.04666337,0.0002254599],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760209,0.00156092,0.00001245436,0.01186873,0.0008127193,0.005239038,0.0005317677,0.000109226,0.003844217],"genre_scores_gemma":[0.9934985,0.001649752,0.0002240888,0.00161561,0.001485602,0.0002969654,0.0002453552,0.00004439236,0.0009397261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04407801,"threshold_uncertainty_score":0.8938717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1136312980238924,"score_gpt":0.3789429370514308,"score_spread":0.2653116390275383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}