{"id":"W3087697977","doi":"10.1016/s1470-2045(20)30494-0","title":"Adjuvant nivolumab versus ipilimumab in resected stage IIIB–C and stage IV melanoma (CheckMate 238): 4-year results from a multicentre, double-blind, randomised, controlled, phase 3 trial","year":2020,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":525,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Bristol-Myers Squibb","keywords":"Ipilimumab; Medicine; Nivolumab; Clinical endpoint; Internal medicine; Population; Clinical trial; Adjuvant; Stage (stratigraphy); Randomized controlled trial; Surgery; Phases of clinical research; Adverse effect; Melanoma; Cancer; Oncology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001655618,0.001566257,0.002672527,0.0003038427,0.0003273711,0.001047361,0.0009469119,0.001477412,0.004353174],"category_scores_gemma":[0.001567202,0.0005872174,0.002263775,0.0002837949,0.0009097054,0.001073027,0.0004190808,0.002991394,0.0009709154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007943745,"about_ca_system_score_gemma":0.0008331866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001342399,"about_ca_topic_score_gemma":0.002786289,"domain_scores_codex":[0.9995242,0.0002337981,0.0000220087,0.0000949641,0.00003536772,0.00008955251],"domain_scores_gemma":[0.999293,0.0002263995,0.0001477505,0.00006425858,0.00003635603,0.0002322541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.975957,0.00275909,0.0005229366,0.0005710783,0.0009608383,0.00002708077,0.00004869155,0.0003942378,0.00238521,0.00006584587,0.0008163307,0.01549161],"study_design_scores_gemma":[0.9482391,0.04739288,0.002249265,0.00004534626,0.0005833021,0.00003271549,0.00002371997,0.0004100803,0.0003519651,0.0001382807,0.0005159918,0.00001724159],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990474,0.005209952,0.000414926,0.0004551739,0.000485743,0.0008627071,0.0007038947,0.0001034075,0.001290046],"genre_scores_gemma":[0.9887844,0.002742016,0.001076513,0.0008067394,0.0003634307,0.001300154,0.001207674,0.00003598771,0.003683181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004353174,"threshold_uncertainty_score":0.01456279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1136312980238924,"score_gpt":0.3789429370514308,"score_spread":0.2653116390275383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}