{"id":"W3087788727","doi":"10.2174/1871524920666200924114524","title":"Effects on the Post-translational Modification of H3K4Me3, H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 Levels in Cerebral Cortex, Hypothalamus and Pons of Rats after a Systemic Administration of Cannabidiol: A Preliminary Study","year":2020,"lang":"en","type":"article","venue":"Central Nervous System Agents in Medicinal Chemistry","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Consejo Nacional de Ciencia y Tecnología","keywords":"Histone H3; H3K4me3; Biology; Neuroscience; Endocrinology; Chemistry; Internal medicine; Histone; Medicine; Genetics; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008386182,0.0004892458,0.0003426501,0.0003596048,0.0003005576,0.0001513968,0.0002007297,0.0002595239,0.002431338],"category_scores_gemma":[0.00007397642,0.0001730128,0.0003629418,0.0001741455,0.0004158621,0.0002079862,0.0001898816,0.0007966741,0.0001995719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003996039,"about_ca_system_score_gemma":0.0003884608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00286878,"about_ca_topic_score_gemma":0.007727099,"domain_scores_codex":[0.9999356,0.000003510169,0.000003636586,0.00001751914,0.00001752606,0.00002215216],"domain_scores_gemma":[0.9999195,0.000005857056,0.00002256603,0.000007677502,0.00001423757,0.00003026891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003395847,0.0003156252,0.0008286559,0.0001742602,0.00003424307,0.000120449,0.00005806418,0.00006277575,0.9910604,0.00006669661,0.00009245383,0.003790471],"study_design_scores_gemma":[0.0002214802,0.007503673,0.03431604,0.00002508765,0.0001492052,0.0003301956,0.0002729204,0.0005210544,0.9539656,0.0001685651,0.00249963,0.00002650577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955884,0.002121975,0.0007043037,0.0001144885,0.00004785986,0.00004542019,0.0005237448,0.00004590079,0.0008080328],"genre_scores_gemma":[0.9900566,0.002605702,0.001339617,0.00009697474,0.00001709137,0.0001073769,0.0004974862,0.00001200885,0.005267066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00286878,"threshold_uncertainty_score":0.00813359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02561113888468287,"score_gpt":0.2817008602424164,"score_spread":0.2560897213577336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}