{"id":"W3087842513","doi":"10.3390/cancers12102766","title":"Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in Acute Myeloid Leukemia","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"European Research Council; Deutsche Krebshilfe","keywords":"Myeloid leukemia; Cancer research; Neuroblastoma RAS viral oncogene homolog; Oncogene; Neuroblastoma; Myeloid; Fusion gene; Carcinogenesis; In vivo; Leukemia; Biology; Chemistry; Medicine; Cancer; Gene; Mutation; Cell culture; Internal medicine; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009253648,0.0002830213,0.0002090794,0.0001164771,0.00007753921,0.000137074,0.000141041,0.0002126964,0.0003030846],"category_scores_gemma":[0.00004848179,0.00008629277,0.000164792,0.0000949262,0.0001360657,0.000116432,0.0001255785,0.0002943428,0.0001181486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829654,"about_ca_system_score_gemma":0.0001301747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004005897,"about_ca_topic_score_gemma":0.0006262461,"domain_scores_codex":[0.9999312,0.000009049864,0.000007182447,0.00001566784,0.00002465495,0.00001220617],"domain_scores_gemma":[0.9999776,0.000003778683,0.000008954695,0.000001955675,0.000002829126,0.000004826523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005016242,0.00002622658,0.00005744408,0.00002836075,0.000003141973,0.00002044771,0.000007405035,0.0001449301,0.9980358,0.00006475503,0.00002579091,0.001535469],"study_design_scores_gemma":[0.00002272467,0.000416216,0.0009376106,0.000002348969,0.00001171376,0.0001788936,0.000007047857,0.001397091,0.9949055,0.00001883029,0.002099308,0.000002728414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935752,0.001513785,0.003805429,0.00005972065,0.00001565436,0.00004757514,0.0001276942,0.00004979797,0.0008052188],"genre_scores_gemma":[0.9951866,0.0009995966,0.002657227,0.0000211707,0.000003389688,0.00004625981,0.0001584584,0.000006986892,0.0009202649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004005897,"threshold_uncertainty_score":0.002053022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00931813820161403,"score_gpt":0.2275328816905101,"score_spread":0.218214743488896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}