{"id":"W3087842513","doi":"10.3390/cancers12102766","title":"Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in Acute Myeloid Leukemia","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"European Research Council; Deutsche Krebshilfe","keywords":"Myeloid leukemia; Cancer research; Neuroblastoma RAS viral oncogene homolog; Oncogene; Neuroblastoma; Myeloid; Fusion gene; Carcinogenesis; In vivo; Leukemia; Biology; Chemistry; Medicine; Cancer; Gene; Mutation; Cell culture; Internal medicine; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000461661,0.00007339047,0.00008009833,0.00001532269,0.00002852852,0.000004157635,0.00009784484,0.0000818031,0.00003527573],"category_scores_gemma":[0.00004260002,0.00005878121,0.00005691134,0.0001667017,0.00005291897,0.000003457496,0.00006745863,0.00007063324,0.000003633714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001695985,"about_ca_system_score_gemma":0.0003689733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000639964,"about_ca_topic_score_gemma":0.0000461872,"domain_scores_codex":[0.9994591,0.00003394722,0.0001485737,0.0001662801,0.00009213205,0.00009994958],"domain_scores_gemma":[0.9997066,0.000001877793,0.00007644207,0.0001383174,0.00003281488,0.00004398239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006323592,0.000002339588,0.0004112233,0.000008884681,0.000009566637,7.441923e-7,0.00007701269,0.0003918124,0.9945285,0.00002260663,0.00334242,0.001141666],"study_design_scores_gemma":[0.0004662663,0.00008255128,0.000909707,0.00001892028,0.000005976682,7.512152e-7,0.00005748698,0.0002712506,0.9800975,0.00002073005,0.01799522,0.00007366524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976585,0.0003786504,0.0001639882,0.0006458894,0.00014549,0.0001723926,0.00002334104,0.00000624885,0.000805496],"genre_scores_gemma":[0.9980421,0.0002149622,0.0001099643,0.001307893,0.0001237954,0.00001471922,0.0000611774,0.000008885665,0.0001165013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0146528,"threshold_uncertainty_score":0.2397028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00931813820161403,"score_gpt":0.2275328816905101,"score_spread":0.218214743488896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}