{"id":"W3087862874","doi":"10.1126/science.abd4570","title":"Inborn errors of type I IFN immunity in patients with life-threatening COVID-19","year":2020,"lang":"en","type":"article","venue":"Science","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":2395,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"NHLBI Division of Intramural Research; National Heart, Lung, and Blood Institute; Uniformed Services University of the Health Sciences; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Georgia Clinical and Translational Science Alliance; George Mason University; Leidos; Frederick National Laboratory for Cancer Research; Mercatus Center, George Mason University; Rockefeller University; Yale University; St. Giles Foundation; U.S. Department of Defense; American Association for the Advancement of Science; National Institutes of Health; Fisher Center for Alzheimer's Research Foundation; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Brigham and Women's Hospital","keywords":"Coronavirus disease 2019 (COVID-19); Immunity; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Medicine; Immunology; Virology; Immune system; Internal medicine; Infectious disease (medical specialty); Disease; Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002504235,0.0005454222,0.0004015828,0.0006883568,0.0005339643,0.0004763131,0.0001976255,0.00109946,0.002147923],"category_scores_gemma":[0.001131597,0.0001809668,0.000243908,0.0004102738,0.0004002254,0.0004116289,0.0002570547,0.001005832,0.0003942775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002762893,"about_ca_system_score_gemma":0.0001416011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003973589,"about_ca_topic_score_gemma":0.0004051949,"domain_scores_codex":[0.9998492,0.00003007286,0.00001690167,0.000034902,0.00003543547,0.00003345646],"domain_scores_gemma":[0.9996355,0.0001072483,0.0001123693,0.00002249414,0.00003202552,0.00009034776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001883947,0.0002180016,0.5777113,0.0001790384,0.0001672444,0.308605,0.0006408945,0.0003948817,0.02486344,0.002704981,0.01508617,0.06754506],"study_design_scores_gemma":[0.0001007918,0.0005238974,0.3478187,0.0002160015,0.0001976716,0.629612,0.0004442448,0.0008917455,0.005520863,0.003705541,0.01093108,0.00003745527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585648,0.01291066,0.002418943,0.007237851,0.0006087417,0.00005431713,0.000417651,0.0002739779,0.01751296],"genre_scores_gemma":[0.9944348,0.002142617,0.0005615992,0.001194805,0.0004243809,0.000007023492,0.0001426574,0.00001756852,0.001074606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002147923,"threshold_uncertainty_score":0.007185459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01855100084308546,"score_gpt":0.2465526628017613,"score_spread":0.2280016619586758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}