{"id":"W3087874008","doi":"10.1016/j.annonc.2020.08.1667","title":"1353P Clinical utility of circulating tumour (ct) DNA next generation sequencing (NGS) for target identification in diagnostic and acquired resistance settings in metastatic NSCLC (mNSCLC): Single centre experience","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"EMD Serono; European Society for Medical Oncology; Genomic Health; AstraZeneca; Celgene; Clovis Oncology; Ariad Pharmaceuticals; Chugai Pharmaceutical; Pfizer; Eli Lilly and Company","keywords":"Medicine; Genotyping; Oncology; Internal medicine; Circulating tumor DNA; Cancer; Genotype; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001439753,0.0004266103,0.0004602879,0.0002620446,0.0002617085,0.0009624431,0.0002543428,0.0006082275,0.002421913],"category_scores_gemma":[0.001997472,0.0001518141,0.0002952677,0.0002624579,0.0005420995,0.0003685554,0.0003729908,0.0006709071,0.0006576192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007213933,"about_ca_system_score_gemma":0.0004975733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002169381,"about_ca_topic_score_gemma":0.002661259,"domain_scores_codex":[0.9995335,0.0001247659,0.00002242823,0.0001364232,0.0001223926,0.00006051962],"domain_scores_gemma":[0.9993579,0.0002545807,0.00004394321,0.00004504466,0.0001464297,0.0001521254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01498669,0.0008193106,0.107467,0.0004449534,0.0002535333,0.01203219,0.001549655,0.00556864,0.2855454,0.0008747271,0.00577157,0.5646864],"study_design_scores_gemma":[0.003247539,0.04626728,0.5300689,0.0005089269,0.001129987,0.06809418,0.001467651,0.03588542,0.2248813,0.003853168,0.08431714,0.0002785259],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767849,0.004084913,0.007307841,0.0008881919,0.0001273133,0.0002079771,0.0008033306,0.0003328067,0.009462732],"genre_scores_gemma":[0.9901276,0.001003072,0.005844931,0.0005399698,0.00005812178,0.00006279808,0.0006424432,0.0001352585,0.001585814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002421913,"threshold_uncertainty_score":0.008102119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.162938646370291,"score_gpt":0.3753820068373604,"score_spread":0.2124433604670694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}