{"id":"W3087874197","doi":"10.1016/j.annonc.2020.08.776","title":"704MO Avelumab first-line (1L) maintenance + best supportive care (BSC) vs BSC alone with 1L chemotherapy (CTx) for advanced urothelial carcinoma (UC): Subgroup analyses from JAVELIN Bladder 100","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Merck KGaA; Pfizer","keywords":"Medicine; Internal medicine; Avelumab; Randomization; Hazard ratio; Gastroenterology; Metastatic Urothelial Carcinoma; Clinical endpoint; Carboplatin; Urology; Bladder cancer; Chemotherapy; Randomized controlled trial; Oncology; Urothelial carcinoma; Cisplatin; Cancer; Nivolumab; Immunotherapy; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001108224,0.0009527099,0.002686645,0.0004586711,0.0002660288,0.001092334,0.00052894,0.00073953,0.003491793],"category_scores_gemma":[0.001589961,0.0004189662,0.009658976,0.0007016042,0.0002816377,0.0006875798,0.0005418363,0.00161263,0.0003051091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006656696,"about_ca_system_score_gemma":0.0008424236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003007381,"about_ca_topic_score_gemma":0.008232231,"domain_scores_codex":[0.9993169,0.0002499528,0.00007600588,0.0001372605,0.00006019606,0.0001596529],"domain_scores_gemma":[0.9994366,0.0002483114,0.0001215269,0.00006756149,0.00002932604,0.0000967435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6974367,0.001179737,0.09304146,0.00636249,0.1152796,0.0004837258,0.0002963711,0.003194162,0.007949552,0.0004309667,0.006579998,0.06776524],"study_design_scores_gemma":[0.2065702,0.05604646,0.4403183,0.001677492,0.2618037,0.0009866899,0.0009984859,0.007896689,0.004676019,0.00272401,0.01596935,0.0003325559],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635354,0.03029574,0.0004555535,0.0004925494,0.0003857763,0.0001958202,0.003014602,0.00004514586,0.001579318],"genre_scores_gemma":[0.9922651,0.00403786,0.0002479462,0.0002946426,0.0001543445,0.0001781305,0.00149549,0.00001576052,0.001310785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003491793,"threshold_uncertainty_score":0.0116812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1064838769351987,"score_gpt":0.390489518559808,"score_spread":0.2840056416246093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}