{"id":"W3087883993","doi":"10.1016/j.annonc.2020.08.2252","title":"LBA23 Pembrolizumab (P) combined with chemotherapy (C) vs C alone as first-line (1L) therapy for advanced urothelial carcinoma (UC): KEYNOTE-361","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Carboplatin; Gemcitabine; Internal medicine; Randomization; Cisplatin; Pembrolizumab; Population; Interim analysis; Oncology; Clinical endpoint; Urology; Metastatic Urothelial Carcinoma; Chemotherapy; Gastroenterology; Randomized controlled trial; Urothelial carcinoma; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001003078,0.0005991465,0.001222708,0.0002834077,0.0003239926,0.000986888,0.000781174,0.001016634,0.0168419],"category_scores_gemma":[0.0008625276,0.0002739297,0.002099676,0.0003492218,0.0002994838,0.000780208,0.0003759438,0.00327128,0.001173062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001162969,"about_ca_system_score_gemma":0.001522654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002163044,"about_ca_topic_score_gemma":0.009573015,"domain_scores_codex":[0.9997037,0.0001287794,0.00001614574,0.00003687193,0.00002657579,0.00008797273],"domain_scores_gemma":[0.9996139,0.0001470805,0.00005264546,0.00001866124,0.00002514622,0.0001425701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6651788,0.01640197,0.001548602,0.003716285,0.002731828,0.0001841005,0.0001332425,0.001631875,0.01328994,0.001674353,0.03642813,0.2570809],"study_design_scores_gemma":[0.4976503,0.3857388,0.02491141,0.001497432,0.008160777,0.000518596,0.0002644992,0.002145512,0.007309907,0.001957478,0.06973237,0.0001129141],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8196028,0.1041537,0.001109177,0.01437363,0.00794828,0.003501928,0.008710525,0.000251713,0.04034836],"genre_scores_gemma":[0.9091265,0.05250825,0.003033239,0.006796125,0.002816065,0.002098158,0.004516294,0.00006877278,0.01903675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0168419,"threshold_uncertainty_score":0.05634171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06526797045284466,"score_gpt":0.3556039308716964,"score_spread":0.2903359604188517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}