{"id":"W3087912192","doi":"10.1093/ofid/ofaa449","title":"Clinical Trials Increase Off-Study Drug Use: A Segmented Time-Series Analysis","year":2020,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University Health Centre","funders":"McGill University Health Centre; McGill University","keywords":"Medicine; Drug; Clinical trial; Series (stratigraphy); Interrupted Time Series Analysis; Pharmacology; Internal medicine; Statistics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02479554,0.0009005539,0.001440095,0.002512698,0.0003143067,0.001787982,0.00134606,0.001090078,0.005280948],"category_scores_gemma":[0.05748609,0.0004303007,0.003597622,0.00238069,0.0008416701,0.001269201,0.001223686,0.001710556,0.0005051623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008378999,"about_ca_system_score_gemma":0.0007630869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00382403,"about_ca_topic_score_gemma":0.001514189,"domain_scores_codex":[0.9786188,0.0144287,0.001632326,0.002805159,0.001731277,0.0007837499],"domain_scores_gemma":[0.8799115,0.09430148,0.01663609,0.005496277,0.002399486,0.001255185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0047672,0.0006207206,0.9051062,0.000682393,0.01053056,0.0007599109,0.0005542675,0.0320204,0.001080653,0.003536124,0.00297533,0.03736616],"study_design_scores_gemma":[0.0002998247,0.002338598,0.5433619,0.0002118441,0.003351586,0.000633209,0.000521454,0.4399818,0.0008739284,0.004455435,0.003885589,0.00008482599],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649522,0.002881763,0.02614025,0.0008599216,0.0001320025,0.0003061964,0.002884548,0.0001868253,0.001656192],"genre_scores_gemma":[0.9938585,0.0002932503,0.002701823,0.0001248291,0.00009166013,0.0001699339,0.002135847,0.00003496658,0.0005892415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02479554,"threshold_uncertainty_score":0.131133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05254089928887185,"score_gpt":0.3878285038806767,"score_spread":0.3352876045918048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}