{"id":"W3087935245","doi":"10.1016/j.annonc.2020.08.1034","title":"919MO ACCURACY a phase II trial of AL101, a selective gamma secretase inhibitor, in subjects with recurrent/metastatic (R/M) adenoid cystic carcinoma (ACC) harboring Notch activating mutations (Notchmut)","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Salivary Gland Tumors Diagnosis and Treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juravinski Cancer Centre","funders":"","keywords":"Medicine; Clinical endpoint; Internal medicine; Surrogate endpoint; Cohort; Notch signaling pathway; Oncology; Cancer; Clinical trial; Gastroenterology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006384907,0.001058435,0.001387289,0.0002994293,0.0003869754,0.0009162425,0.0006265279,0.001345791,0.008852256],"category_scores_gemma":[0.0004733414,0.0004174521,0.001115993,0.0002733427,0.0005532029,0.0005805956,0.0002671388,0.002691827,0.002738308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005057901,"about_ca_system_score_gemma":0.0009622964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001050696,"about_ca_topic_score_gemma":0.003165853,"domain_scores_codex":[0.9997612,0.00009161147,0.00001070522,0.00005343909,0.000021083,0.00006191203],"domain_scores_gemma":[0.9997496,0.0000476642,0.000030487,0.00001942047,0.00002399884,0.0001288136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6763194,0.03396178,0.009674172,0.00104613,0.003651974,0.0003653977,0.0002310121,0.001608314,0.05670055,0.0007995354,0.01280358,0.2028382],"study_design_scores_gemma":[0.7371472,0.2323198,0.01473998,0.0000702278,0.001260953,0.0004132657,0.0001103194,0.001361787,0.004320791,0.0004952297,0.007709514,0.0000509455],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813462,0.004180904,0.0007476378,0.00178568,0.0004979876,0.001568306,0.001825302,0.000373591,0.007674363],"genre_scores_gemma":[0.9782676,0.002611467,0.001616309,0.002381369,0.0002286689,0.001178237,0.003743331,0.0000524641,0.009920519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008852256,"threshold_uncertainty_score":0.02961373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1030227238127281,"score_gpt":0.3917898624428706,"score_spread":0.2887671386301425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}