{"id":"W3087941421","doi":"10.1016/j.annonc.2020.08.1893","title":"1668TiP A multicenter, open-label, randomized phase II study to compare the efficacy and safety of lenvatinib in combination with ifosfamide and etoposide versus ifosfamide and etoposide in children, adolescents and young adults with relapsed or refractory osteosarcoma (OLIE; ITCC-082)","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Merck Sharp and Dohme; Eisai","keywords":"Medicine; Ifosfamide; Etoposide; Internal medicine; Lenvatinib; Surgery; Chemotherapy regimen; Gastroenterology; Chemotherapy; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001233724,0.00156995,0.00257466,0.0003978793,0.0004210151,0.001069433,0.0009624276,0.002011979,0.01409832],"category_scores_gemma":[0.001223349,0.0007137151,0.001619641,0.0004400575,0.0008243965,0.0009657807,0.0004079754,0.004296492,0.002858935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008838839,"about_ca_system_score_gemma":0.001592308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000853077,"about_ca_topic_score_gemma":0.003152345,"domain_scores_codex":[0.9994501,0.0003022597,0.00002963556,0.00009872767,0.00003499584,0.00008414911],"domain_scores_gemma":[0.9993314,0.0001297353,0.000157566,0.00005279139,0.00004727854,0.0002812402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9357805,0.01396098,0.00145222,0.0007086288,0.001285748,0.00007117358,0.00005376451,0.000540158,0.006647163,0.0002824128,0.005800518,0.03341661],"study_design_scores_gemma":[0.9366481,0.05900141,0.001467705,0.00002704098,0.0003236819,0.00004614814,0.00001495731,0.0002580782,0.00033544,0.000105645,0.001760141,0.00001178947],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611527,0.00575093,0.001344369,0.002433971,0.001099175,0.008886169,0.008992418,0.0004673806,0.009872938],"genre_scores_gemma":[0.947136,0.003322975,0.005731615,0.006144251,0.0008644079,0.01160541,0.01311462,0.0001302278,0.01195051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01409832,"threshold_uncertainty_score":0.04716355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0634064902655568,"score_gpt":0.3731882440107652,"score_spread":0.3097817537452084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}