{"id":"W3087962472","doi":"10.1002/cpmc.116","title":"Experimental Evolution of Antifungal Resistance in <i>Cryptococcus neoformans</i>","year":2020,"lang":"en","type":"article","venue":"Current Protocols in Microbiology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"University of Guelph","keywords":"Cryptococcus neoformans; Biology; Microbiology; Cryptococcus; Antifungal; Drug resistance; Antifungal drug; Cryptococcosis; Cryptococcal meningitis; Human pathogen; Fluconazole; Pathogen; Virology; Genetics; Bacteria; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009424579,0.0008274746,0.0002527435,0.0006178607,0.0005627855,0.000316807,0.0008585945,0.0006062057,0.003052533],"category_scores_gemma":[0.0009877952,0.0003202494,0.0004259142,0.0006030791,0.0004315893,0.0003414247,0.0005328404,0.0009841514,0.001294613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000520486,"about_ca_system_score_gemma":0.0007111991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002532238,"about_ca_topic_score_gemma":0.004384686,"domain_scores_codex":[0.9987759,0.0002630957,0.0001815957,0.000245505,0.0003907782,0.0001431147],"domain_scores_gemma":[0.9991031,0.0002477094,0.0001584584,0.0002359122,0.0001955619,0.00005937717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001654109,0.0001809783,0.0007511469,0.00009063819,0.000008153673,0.0001162902,0.00004912321,0.0001955126,0.9934857,0.0002771466,0.0004821479,0.004197642],"study_design_scores_gemma":[0.00001504876,0.0006068651,0.003744547,0.00003753351,0.00001581648,0.0002023016,0.00003733063,0.0005507931,0.9884389,0.00008062971,0.006250114,0.00002004855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9096065,0.001848207,0.04933167,0.0009575402,0.0003872007,0.005370262,0.0132229,0.001147588,0.01812817],"genre_scores_gemma":[0.7455616,0.003621886,0.1977483,0.001006455,0.0000974354,0.005632037,0.02862068,0.0004278775,0.01728384],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.003052533,"threshold_uncertainty_score":0.01021177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04249319057351274,"score_gpt":0.3468630503727771,"score_spread":0.3043698597992643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}