{"id":"W3087963873","doi":"10.1016/j.annonc.2020.08.2299","title":"LBA9_PR Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer (EC/GEJC) following neoadjuvant chemoradiation therapy (CRT): First results of the CheckMate 577 study","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Bristol-Myers Squibb","keywords":"Medicine; Nivolumab; Internal medicine; Adverse effect; Placebo; Neoadjuvant therapy; Esophageal cancer; Adjuvant therapy; Clinical endpoint; Interim analysis; Randomized controlled trial; Oncology; Gastroenterology; Surgery; Cancer; Breast cancer; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009940506,0.0006075407,0.001183821,0.0001971651,0.000210438,0.001021374,0.0004935453,0.000612041,0.00182788],"category_scores_gemma":[0.001151426,0.0003506278,0.001951765,0.0003377248,0.0003623567,0.0006454044,0.0003785029,0.001160049,0.0005025412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000599906,"about_ca_system_score_gemma":0.0005385379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001719817,"about_ca_topic_score_gemma":0.004925569,"domain_scores_codex":[0.9996946,0.0001135181,0.00002574916,0.00007487822,0.00003890481,0.00005241349],"domain_scores_gemma":[0.999391,0.0001785066,0.000162999,0.00008760059,0.00005068473,0.0001293059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5111015,0.004068096,0.3026829,0.002576925,0.01372352,0.0003347743,0.0001799353,0.001709935,0.009799121,0.0002980234,0.004738714,0.1487867],"study_design_scores_gemma":[0.1066958,0.08603408,0.7552835,0.000681597,0.03304844,0.0005790194,0.0002809411,0.002171529,0.003501506,0.0006407895,0.01096415,0.0001187812],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899737,0.007106494,0.0001262591,0.0001842375,0.000122326,0.00009316433,0.001084618,0.00001730384,0.001291859],"genre_scores_gemma":[0.9918851,0.003149423,0.0002727373,0.00039642,0.0001569253,0.0000882374,0.002829248,0.00001388314,0.001208066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00182788,"threshold_uncertainty_score":0.006114841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1292241046367297,"score_gpt":0.411330702803153,"score_spread":0.2821065981664233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}