{"id":"W3087985205","doi":"10.1016/j.theriogenology.2020.09.027","title":"Specific imprinted genes demethylation in association with oocyte donor’s age and culture conditions in bovine embryos assessed at day 7 and 12 post insemination","year":2020,"lang":"en","type":"article","venue":"Theriogenology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"L'Alliance Boviteq; Université Laval","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Fiona Stanley Hospital; Lyda Hill Foundation","keywords":"Genomic imprinting; Andrology; Biology; Oocyte; Embryo; Embryo culture; Insemination; Embryogenesis; Methylation; Estrous cycle; Human fertilization; DNA methylation; Genetics; Endocrinology; Gene expression; Gene; Pregnancy; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001384004,0.000116075,0.0001521214,0.00005300892,0.00004678101,0.00001802375,0.00005472272,0.0001859239,0.00002320276],"category_scores_gemma":[0.00006868109,0.000107929,0.00001542952,0.0001012398,0.00004445465,0.000006782843,0.0000879419,0.00008395638,0.000002638866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004159836,"about_ca_system_score_gemma":0.00002033468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000585313,"about_ca_topic_score_gemma":0.0006008781,"domain_scores_codex":[0.9992062,0.0001032744,0.0001774038,0.0002863393,0.00005645378,0.0001702593],"domain_scores_gemma":[0.9996948,0.00001854192,0.0001054216,0.00009424273,0.00004518528,0.00004186981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004812144,0.00001728301,0.1545457,0.00001018838,0.0000212593,0.000005710389,0.0006047042,0.00001976017,0.8430147,0.00001785515,0.00001755411,0.001677249],"study_design_scores_gemma":[0.001141574,0.0004809299,0.8895227,0.000010895,0.00001253661,0.00002842767,0.0002736894,0.000183758,0.1043902,0.00004127498,0.003756025,0.0001580301],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974461,0.001093414,0.0003428776,0.0006397466,0.00002941136,0.0002090818,0.00001439453,0.000008650723,0.0002163049],"genre_scores_gemma":[0.9980421,0.0008513533,0.0005228277,0.0001691541,0.00004391864,0.00001692338,0.0002179072,0.00001424505,0.0001215768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7386244,"threshold_uncertainty_score":0.4401215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01051924118651161,"score_gpt":0.2272592706318375,"score_spread":0.2167400294453259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}