{"id":"W3087985540","doi":"10.1016/j.annonc.2020.08.819","title":"747P Association of TMB with efficacy of pembrolizumab (pembro) in patients (pts) with advanced urothelial cancer (UC): Results from KEYNOTE-045 and KEYNOTE-052","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Merck Sharp and Dohme","keywords":"Medicine; Docetaxel; Internal medicine; Oncology; Pembrolizumab; Clinical trial; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001731981,0.0002485256,0.0005782645,0.0002794245,0.0001985831,0.0007161961,0.0002899957,0.0005951849,0.004417971],"category_scores_gemma":[0.003042686,0.0001797853,0.001274847,0.0004463039,0.000173999,0.0006272649,0.0003246689,0.001079172,0.0006144356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003938995,"about_ca_system_score_gemma":0.0004359598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171458,"about_ca_topic_score_gemma":0.001745723,"domain_scores_codex":[0.9994851,0.0001947866,0.00004442091,0.00009254689,0.0001085812,0.00007454764],"domain_scores_gemma":[0.9981781,0.0007220868,0.0005637499,0.000104216,0.0001883148,0.0002434486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2934254,0.003198551,0.5532761,0.0008081309,0.007804317,0.0001674341,0.0001078473,0.00127093,0.01042782,0.0002093153,0.009384394,0.1199199],"study_design_scores_gemma":[0.008820732,0.02922834,0.9513913,0.00007234489,0.002988156,0.0001839524,0.00006440775,0.0009256389,0.001525484,0.0001523413,0.004617724,0.00002969051],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856381,0.005627818,0.0002107908,0.0007579646,0.0001736654,0.0001017547,0.004002419,0.00003567743,0.003451833],"genre_scores_gemma":[0.9929076,0.0009961326,0.0002623388,0.0004812542,0.000231598,0.0000729857,0.002723654,0.00001020449,0.002314135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004417971,"threshold_uncertainty_score":0.01477963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03333975512778601,"score_gpt":0.3257186515375333,"score_spread":0.2923788964097473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}