{"id":"W3088045753","doi":"10.1016/j.ejmech.2020.112863","title":"Amphiphilic desmuramyl peptides for the rational design of new vaccine adjuvants: Synthesis, in vitro modulation of inflammatory response and molecular docking studies","year":2020,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Energy; NOSM University; Lakehead University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Muramyl dipeptide; Chemistry; NOD2; Rational design; Docking (animal); Stereochemistry; Dipeptide; Biochemistry; In vitro; Receptor; Innate immune system; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002693897,0.0003409731,0.000246269,0.0001068506,0.00009267857,0.0001996412,0.0001853148,0.0002008967,0.0006839784],"category_scores_gemma":[0.0002310469,0.0001176005,0.0001842727,0.0001355341,0.0001127091,0.0003078243,0.0001948481,0.000606377,0.0002581356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001688758,"about_ca_system_score_gemma":0.0001991102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001477018,"about_ca_topic_score_gemma":0.0003386905,"domain_scores_codex":[0.9999502,0.0000131385,0.000004271703,0.000006394954,0.00001271113,0.00001329596],"domain_scores_gemma":[0.9999349,0.00001522862,0.00001932281,0.000005243942,0.00001103294,0.00001417181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004016033,0.0001558478,0.0001870311,0.0002333472,0.00001424971,0.000170063,0.00005292593,0.006541776,0.9784682,0.001141367,0.0001387924,0.01249476],"study_design_scores_gemma":[0.000155606,0.001822194,0.0004781334,0.00003382592,0.00003464809,0.0002636407,0.0000394734,0.009202817,0.9794541,0.0003140096,0.0081797,0.00002181528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749527,0.003869025,0.01933964,0.0001684094,0.0000417844,0.0001615319,0.0002344864,0.00005560041,0.001176756],"genre_scores_gemma":[0.975589,0.003684516,0.01876335,0.00006016949,0.00001218712,0.0001021615,0.0003108755,0.00001653869,0.001461174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006839784,"threshold_uncertainty_score":0.002288163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03315326691480418,"score_gpt":0.2597577051853577,"score_spread":0.2266044382705535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}