{"id":"W3088071745","doi":"10.2174/0929867327666200923151924","title":"Repurposing of the PDE5 Inhibitor Sildenafil for the Treatment of Persistent Pulmonary Hypertension in Neonates","year":2020,"lang":"en","type":"article","venue":"Current Medicinal Chemistry","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"MacEwan University; University of Alberta","funders":"","keywords":"Sildenafil; cGMP-specific phosphodiesterase type 5; Cyclic guanosine monophosphate; Nitric oxide; Erectile dysfunction; Pharmacology; Medicine; Pulmonary hypertension; cGMP-dependent protein kinase; Phosphodiesterase inhibitor; Guanosine monophosphate; Phosphodiesterase; Internal medicine; Endocrinology; Chemistry; Protein kinase A; Kinase; Enzyme; Biochemistry; Nucleotide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001712254,0.0002963996,0.0003299463,0.0005760372,0.0001408204,0.0003648194,0.0002649919,0.0003993861,0.003170673],"category_scores_gemma":[0.0002549517,0.0001013113,0.000302797,0.0002688135,0.00009923796,0.0003235016,0.0002382226,0.0008786597,0.00127516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002328539,"about_ca_system_score_gemma":0.0003167578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002984335,"about_ca_topic_score_gemma":0.0007724767,"domain_scores_codex":[0.9999241,0.00001441167,0.0000126298,0.00001152526,0.00002534789,0.00001199687],"domain_scores_gemma":[0.9999357,0.00001912765,0.00001682285,0.000002045053,0.00001628742,0.000009904007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0005931911,0.0002161454,0.0004735167,0.0076978,0.0001534792,0.001331296,0.0001392272,0.000669728,0.05690017,0.004650727,0.038339,0.8888357],"study_design_scores_gemma":[0.0001195748,0.001586863,0.002643136,0.001155718,0.0002497487,0.004600589,0.00005994447,0.0005275821,0.02701057,0.001314796,0.9606932,0.00003837991],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.006886743,0.9816384,0.001248525,0.001177662,0.0009122864,0.00004436815,0.0002010197,0.00007045046,0.007820509],"genre_scores_gemma":[0.03568107,0.9530573,0.001542046,0.001563288,0.0008801162,0.00004599471,0.0005909131,0.00001310844,0.006626177],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003170673,"threshold_uncertainty_score":0.01060694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06524488224877158,"score_gpt":0.3035141581640279,"score_spread":0.2382692759152563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}