{"id":"W3088110723","doi":"10.1016/j.ymthe.2020.09.019","title":"Gene Therapy for Hemophilia: Are Expectations Matching Reality?","year":2020,"lang":"en","type":"letter","venue":"Molecular Therapy","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Genetic enhancement; Matching (statistics); Medicine; Gene; Biology; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09321532,0.0006298543,0.001788531,0.001147924,0.00320998,0.01498481,0.002587717,0.008677118,0.01602017],"category_scores_gemma":[0.2526672,0.0004986476,0.0008643027,0.001442788,0.01079858,0.01959428,0.005391725,0.02544444,0.007334909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007529586,"about_ca_system_score_gemma":0.01181234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003911656,"about_ca_topic_score_gemma":0.005007912,"domain_scores_codex":[0.9320822,0.04142305,0.003524599,0.003787361,0.01696104,0.002221691],"domain_scores_gemma":[0.8316293,0.1163021,0.01141122,0.004482843,0.02144612,0.01472838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005594025,0.0001764263,0.004297004,0.001141017,0.0001262395,0.0004149456,0.003007635,0.0003346987,0.0003394475,0.06779502,0.7728341,0.148974],"study_design_scores_gemma":[0.0002946348,0.0006071751,0.006112364,0.007332208,0.0001472301,0.0008452614,0.01123135,0.0008142283,0.0004071676,0.2763404,0.6956417,0.0002263846],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001056021,0.01110386,0.0008798001,0.9767684,0.00312076,0.00001854106,0.0001883478,0.00004634565,0.00681795],"genre_scores_gemma":[0.07645124,0.02860629,0.002780581,0.8746863,0.01261213,0.0002501301,0.0006639444,0.0002745934,0.003674853],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.09321532,"threshold_uncertainty_score":0.4929756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06065774699197732,"score_gpt":0.3402432995471547,"score_spread":0.2795855525551774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}