{"id":"W3088110723","doi":"10.1016/j.ymthe.2020.09.019","title":"Gene Therapy for Hemophilia: Are Expectations Matching Reality?","year":2020,"lang":"en","type":"letter","venue":"Molecular Therapy","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Genetic enhancement; Matching (statistics); Medicine; Gene; Biology; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001079067,0.0005349508,0.000827215,0.000223754,0.0002228711,0.00008154911,0.0002964261,0.0006289772,0.0001455299],"category_scores_gemma":[0.00003662281,0.0004166577,0.0007065424,0.0002777305,0.00009893197,0.00004291379,0.00003277384,0.001184356,0.0001078908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001387358,"about_ca_system_score_gemma":0.0002382431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002424193,"about_ca_topic_score_gemma":8.168117e-7,"domain_scores_codex":[0.997277,0.0001679396,0.0003927868,0.000794848,0.0007417061,0.0006257672],"domain_scores_gemma":[0.9984964,0.0001436295,0.0001672289,0.0007866631,0.0002265392,0.0001795555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009394311,0.0003522614,0.0001261964,0.0003546546,0.002236263,0.007817133,0.001236622,0.000003683773,0.07427846,0.00003452045,0.8955444,0.01707638],"study_design_scores_gemma":[0.006076288,0.001077926,0.000108546,0.0001602916,0.0001123423,0.0000844866,0.0001258588,0.00003443985,0.0877649,0.003620972,0.9002584,0.0005755065],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02247141,0.00730332,0.001578328,0.9643688,0.0002140567,0.00314774,0.0001758333,0.0002132917,0.000527197],"genre_scores_gemma":[0.01531106,0.003777713,0.003208491,0.9605669,0.005104843,0.001317862,0.004354172,0.0004151514,0.005943845],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01650087,"threshold_uncertainty_score":0.9998285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06065774699197732,"score_gpt":0.3402432995471547,"score_spread":0.2795855525551774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}