{"id":"W3088206321","doi":"10.1242/dev.194886","title":"Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity","year":2020,"lang":"en","type":"article","venue":"Development","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"NEDD8; Neddylation; Biology; Cullin; Cell biology; Zebrafish; Androgen receptor; ATG12; Androgen; Ubiquitin; Endocrinology; Genetics; Apoptosis; Autophagy; Ubiquitin ligase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003043696,0.0001517423,0.0002472234,0.00001603203,0.00008224935,0.000009740447,0.0001553629,0.00008950033,0.00004206602],"category_scores_gemma":[0.00009302781,0.0001116596,0.00003020803,0.00005627707,0.0001418364,0.000005425609,0.0002380379,0.00009142389,0.000005400468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001044174,"about_ca_system_score_gemma":0.0002598543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004960208,"about_ca_topic_score_gemma":0.000003295365,"domain_scores_codex":[0.9990132,0.0000812912,0.0003220526,0.0002690834,0.0001395614,0.0001748394],"domain_scores_gemma":[0.9994808,0.00002547122,0.0001753816,0.0001504345,0.00008094505,0.00008698652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000934506,0.0000669151,0.003844754,0.0003159063,0.00014149,0.000001881439,0.006775468,8.437198e-7,0.8912058,0.00003518011,0.0004848776,0.0961924],"study_design_scores_gemma":[0.000932134,0.00009681057,0.0169546,0.00002832593,0.000006209615,0.000003554142,0.0002702134,0.00002151787,0.9179044,0.000006920634,0.06363071,0.0001445895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969445,0.0001819121,0.001958207,0.0002900478,0.00005987814,0.000297315,0.00007100618,0.000007287809,0.0001897927],"genre_scores_gemma":[0.9929762,0.00002974791,0.006394337,0.0001999008,0.00003484655,0.00003678513,0.0001579442,0.00001187204,0.0001583693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0960478,"threshold_uncertainty_score":0.4553345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01625538688365448,"score_gpt":0.2175286400203442,"score_spread":0.2012732531366897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}