{"id":"W3088206321","doi":"10.1242/dev.194886","title":"Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity","year":2020,"lang":"en","type":"article","venue":"Development","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"NEDD8; Neddylation; Biology; Cullin; Cell biology; Zebrafish; Androgen receptor; ATG12; Androgen; Ubiquitin; Endocrinology; Genetics; Apoptosis; Autophagy; Ubiquitin ligase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000861369,0.000235648,0.000138349,0.0001917245,0.0001097404,0.0001358822,0.0001572459,0.000150125,0.001549114],"category_scores_gemma":[0.00005926074,0.0001247934,0.0001824217,0.000049741,0.0002086046,0.0001067667,0.0001933984,0.0003294965,0.0002119597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003108493,"about_ca_system_score_gemma":0.0001837795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186454,"about_ca_topic_score_gemma":0.002548934,"domain_scores_codex":[0.9999363,0.000005871729,0.000006605932,0.00001860186,0.00001870506,0.00001389534],"domain_scores_gemma":[0.9999344,0.000004732416,0.00002503135,0.000005942303,0.000006577041,0.00002331363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002969391,0.000004519585,0.0001524795,0.00001328766,0.000001234123,0.00003723307,0.000005898277,0.00001739672,0.999256,0.00007723933,0.00001657703,0.0003884662],"study_design_scores_gemma":[0.0000199404,0.0001625271,0.01028986,0.000004170911,0.0000116401,0.0001964293,0.00002013649,0.0007362876,0.9852731,0.00003761898,0.003243671,0.000004674648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934215,0.0007171266,0.00292568,0.00007874663,0.00003095773,0.0000185171,0.0004274064,0.000111519,0.002268496],"genre_scores_gemma":[0.9902471,0.0002754852,0.00150013,0.00003665494,0.000004448517,0.00002104673,0.0002827437,0.00002372546,0.007608676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001549114,"threshold_uncertainty_score":0.005182326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01625538688365448,"score_gpt":0.2175286400203442,"score_spread":0.2012732531366897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}