{"id":"W3088206657","doi":"10.1101/2020.09.22.303438","title":"Genes on Different Strands Mark Boundaries Associated with Co-regulation Domains","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Hôtel-Dieu de Québec; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Genome Canada","keywords":"Gene; Biology; CTCF; Chromatin; Expression quantitative trait loci; Genetics; Gene expression; Regulation of gene expression; Computational biology; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955708,0.000208411,0.0003115997,0.0005590735,0.0002423687,0.000585706,0.0001814937,0.0003314303,0.002472596],"category_scores_gemma":[0.0005494208,0.00020153,0.0002261067,0.0005099893,0.0003749238,0.0002886103,0.0005029104,0.0004220967,0.0009684846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002121736,"about_ca_system_score_gemma":0.0001585183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004586068,"about_ca_topic_score_gemma":0.0007756131,"domain_scores_codex":[0.9996575,0.0000252041,0.00001406052,0.000164976,0.00007700686,0.00006129962],"domain_scores_gemma":[0.9993927,0.0001421399,0.0002137667,0.00008828208,0.00007246445,0.00009060545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003734106,0.00002164048,0.03399074,0.0001160968,0.00003250682,0.0001447607,0.00007832981,0.0003408517,0.9594856,0.0006869949,0.0002622298,0.004466873],"study_design_scores_gemma":[0.00004012374,0.0001636317,0.5398226,0.00005006369,0.0001156112,0.0009947399,0.0003033234,0.006417788,0.4426374,0.0026679,0.00675111,0.00003575298],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889197,0.0005609823,0.006778067,0.00005016114,0.00003094561,0.00001025107,0.00152655,0.0002047963,0.001918577],"genre_scores_gemma":[0.9941998,0.00008887945,0.003171608,0.00004124521,0.00001132016,0.00001063016,0.001519658,0.00005121274,0.0009056482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002472596,"threshold_uncertainty_score":0.008271694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00845229642480327,"score_gpt":0.2044112000675755,"score_spread":0.1959589036427722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}