{"id":"W3088256443","doi":"10.1126/science.abd4585","title":"Autoantibodies against type I IFNs in patients with life-threatening COVID-19","year":2020,"lang":"en","type":"article","venue":"Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2849,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"NHLBI Division of Intramural Research; Instituto de Salud Carlos III; National Health and Medical Research Council; Mercatus Center, George Mason University; Novo Nordisk Fonden; Uniformed Services University of the Health Sciences; American Association for the Advancement of Science; National Institutes of Health; National Center for Advancing Translational Sciences; Medical Research Council; Regione Lombardia; Fondation pour la Recherche Médicale; European Commission; Ministerio de Ciencia e Innovación; Fondazione Telethon; ZonMw; Institut National de la Santé et de la Recherche Médicale; U.S. Department of Defense; Agencia Estatal de Investigación; University of New South Wales; Yale University; National Human Genome Research Institute; Amsterdam University Medical Centers; Institut des maladies génétiques Imagine; George Mason University; St. Giles Foundation; Fondation Bettencourt Schueller; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; Georgia Clinical and Translational Science Alliance; Howard Hughes Medical Institute","keywords":"Autoantibody; Immunology; Asymptomatic; Medicine; Pneumonia; Antibody; Phenocopy; Coronavirus; Disease; Coronavirus disease 2019 (COVID-19); Internal medicine; Biology; Infectious disease (medical specialty); Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000324191,0.0004419163,0.0004542611,0.0008513003,0.0007007035,0.0005277905,0.0002153739,0.001316772,0.002218851],"category_scores_gemma":[0.001281237,0.0002510166,0.0002992655,0.0005614118,0.0003949021,0.0005724683,0.0002682659,0.0009489074,0.0004001331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003551822,"about_ca_system_score_gemma":0.000176668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008440342,"about_ca_topic_score_gemma":0.0008452966,"domain_scores_codex":[0.9997812,0.00004780424,0.00003161319,0.00004939217,0.00004730628,0.00004272637],"domain_scores_gemma":[0.9994383,0.0001333288,0.0001419164,0.00002827008,0.00007623124,0.0001819214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001146245,0.0001418375,0.9136479,0.00007614609,0.00007727982,0.04764083,0.0004702759,0.0001580642,0.008906538,0.000449087,0.005038497,0.02224717],"study_design_scores_gemma":[0.0001563847,0.0008651636,0.8066155,0.0001713213,0.0001619848,0.1797469,0.0006520501,0.000808019,0.002184304,0.001583557,0.007014331,0.00004054223],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751229,0.006274997,0.0006562952,0.004170489,0.0002350098,0.00004748821,0.0002993364,0.0001009309,0.01309248],"genre_scores_gemma":[0.9972783,0.000786075,0.0002483796,0.0008440554,0.000220163,0.000006822735,0.0001353973,0.000006718918,0.0004741412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002218851,"threshold_uncertainty_score":0.007422745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06025604938594161,"score_gpt":0.3570680664054836,"score_spread":0.296812017019542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}