{"id":"W3088272124","doi":"10.1002/ijc.33308","title":"Evaluating the role of alcohol consumption in breast and ovarian cancer susceptibility using population‐based cohort studies and two‐sample Mendelian randomization analyses","year":2020,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; National Center for Advancing Translational Sciences; Instituto de Salud Carlos III; Cancer Council Victoria; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Health Canada; National Institutes of Health; Japan Society for the Promotion of Science; Ministry of Health, Labour and Welfare; Hellenic Health Foundation; Deutsche Krebshilfe; Institut Gustave-Roussy; QIMR Berghofer Medical Research Institute; Norges Forskningsråd; NordForsk; Horizon 2020 Framework Programme; Vetenskapsrådet; Helse Vest; Mutuelle Générale de l'Education Nationale; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Institut National de la Santé et de la Recherche Médicale; Cancerfonden; National Cancer Institute; University College London; Cancer Institute NSW; European Commission; Minnesota Ovarian Cancer Alliance; Moffitt Cancer Center; University of Cambridge; Fred C. and Katherine B. Andersen Foundation; Government of Canada; Roswell Park Cancer Institute; National Institute for Health and Care Research; Associazione Italiana per la Ricerca sul Cancro; Cancer Research UK; U.S. Department of Defense; Genome Canada; Radboud Universiteit; Lon V. Smith Foundation; Wellcome Trust; Swedish Cancer Foundation; Cancer Research Society; University of Pittsburgh; Pomorski Uniwersytet Medyczny W Szczecinie; Ligue Contre le Cancer; Vanderbilt University Medical Center; Deutsches Krebsforschungszentrum; Rutgers Cancer Institute of New Jersey; Mayo Foundation for Medical Education and Research; Korea Health Industry Development Institute; Oregon Health and Science University; Vanderbilt University; BC Cancer Foundation; Oak Foundation","keywords":"Mendelian randomization; Medicine; Observational study; Breast cancer; Confidence interval; Confounding; Hazard ratio; Cohort study; Oncology; Population; Internal medicine; Cohort; Gynecology; Cancer; Environmental health; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1579923,0.001811206,0.002622175,0.002918396,0.0008446078,0.002205715,0.002852289,0.002424574,0.001911042],"category_scores_gemma":[0.2599739,0.001338879,0.008677946,0.003453965,0.001761613,0.001723427,0.001563058,0.001431537,0.000179401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008447196,"about_ca_system_score_gemma":0.001368282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002942122,"about_ca_topic_score_gemma":0.002299156,"domain_scores_codex":[0.7208687,0.238096,0.0128535,0.01614331,0.01040273,0.001635796],"domain_scores_gemma":[0.7407767,0.1882754,0.0293294,0.03679153,0.003962377,0.0008646959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01847067,0.0004908043,0.6665527,0.003852437,0.2071699,0.001947434,0.00136083,0.01157511,0.005450726,0.0211948,0.002351586,0.05958295],"study_design_scores_gemma":[0.009717749,0.01140526,0.5848187,0.001108868,0.1471624,0.003705091,0.0005751345,0.1688357,0.007063047,0.04905125,0.01590892,0.0006479031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5507653,0.01577332,0.4249741,0.001279572,0.000863515,0.002467694,0.001621245,0.0007075348,0.001547701],"genre_scores_gemma":[0.9227638,0.001105769,0.07286613,0.000453011,0.0001941843,0.001742201,0.0004624346,0.000107028,0.0003054295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1579923,"threshold_uncertainty_score":0.8355534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1189586193750339,"score_gpt":0.4701835401735692,"score_spread":0.3512249207985353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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