{"id":"W3088306168","doi":"10.1016/j.celrep.2020.108169","title":"Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"National Institute of General Medical Sciences; Heart and Stroke Foundation of Canada; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Army Medical University","keywords":"Neuroscience; Ryanodine receptor 2; Hippocampal formation; Alzheimer's disease; Memory impairment; Amyloid (mycology); Medicine; Biology; Ryanodine receptor; Internal medicine; Disease; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001787673,0.0004036223,0.0006297943,0.0002181203,0.000158612,0.000366428,0.0003751196,0.0003939384,0.001526165],"category_scores_gemma":[0.0002138415,0.0001388952,0.0003084845,0.0001174818,0.0003223099,0.0003851507,0.0001829621,0.0008999277,0.0005867776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897426,"about_ca_system_score_gemma":0.0003298658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006451664,"about_ca_topic_score_gemma":0.001507483,"domain_scores_codex":[0.9998738,0.00001432654,0.00001456217,0.00002954426,0.00002202929,0.00004578968],"domain_scores_gemma":[0.9998639,0.00001656343,0.00003450069,0.00001974542,0.00001753904,0.00004780532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007359202,0.0002065155,0.0001233012,0.0000804966,0.0000163855,0.00003877411,0.00001967765,0.00005213662,0.9940251,0.0001278525,0.000224997,0.004348997],"study_design_scores_gemma":[0.000204611,0.00242462,0.005133598,0.00002012675,0.00008088029,0.0003522613,0.00006954963,0.0007272544,0.986478,0.0002167948,0.004273072,0.00001925988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993208,0.002084756,0.001833444,0.0001657318,0.0000914091,0.0000323919,0.0003739039,0.0002393321,0.001970952],"genre_scores_gemma":[0.9938876,0.001390189,0.001353022,0.0001206583,0.0000318716,0.00005943053,0.0005042154,0.00005805106,0.002595137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001526165,"threshold_uncertainty_score":0.005105555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.134458187319053,"score_gpt":0.3639540431778164,"score_spread":0.2294958558587634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}