{"id":"W3088314665","doi":"10.1161/hypertensionaha.120.15829","title":"Clinical and Proteomic Correlates of Plasma ACE2 (Angiotensin-Converting Enzyme 2) in Human Heart Failure","year":2020,"lang":"en","type":"article","venue":"Hypertension","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"National Heart, Lung, and Blood Institute; National Institute on Aging; Bristol-Myers Squibb; Ironwood Pharmaceuticals, Incorporated; Edwards Lifesciences; National Institutes of Health; Pfizer","keywords":"Angiotensin-converting enzyme 2; Heart failure; Internal medicine; Endocrinology; Diabetes mellitus; Medicine; Angiotensin II; Renin–angiotensin system; Exocytosis; Endocytosis; Receptor; Biology; Blood pressure; Disease; Coronavirus disease 2019 (COVID-19); Secretion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003555502,0.000217285,0.001054822,0.000100702,0.00007447798,0.000008743461,0.00005619982,0.0002362183,0.000009932026],"category_scores_gemma":[0.0006869463,0.0001726846,0.0001667286,0.000223218,0.0002167443,0.00006481793,0.0001509064,0.000361709,0.00003052914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000175946,"about_ca_system_score_gemma":0.00004305313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006142566,"about_ca_topic_score_gemma":0.00001262308,"domain_scores_codex":[0.9980632,0.0001238408,0.0008171473,0.0004691519,0.0002556145,0.0002710383],"domain_scores_gemma":[0.9990376,0.0001557846,0.000174242,0.0002528158,0.0002019646,0.0001776024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002087772,0.0000555618,0.6441177,0.00006209053,0.0000642545,0.0001047793,0.000469589,0.000004300416,0.3457254,0.00001292488,0.008849971,0.0003246997],"study_design_scores_gemma":[0.004823583,0.001020214,0.9411469,0.001203341,0.0001980331,0.0005672075,0.0003548659,0.005909863,0.04281488,0.00001830559,0.001661422,0.0002814062],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885725,0.0006696217,0.000008755231,0.009779529,0.0001243718,0.0007048186,0.00000184707,0.0000676036,0.00007098349],"genre_scores_gemma":[0.9962175,0.00003278672,0.00238403,0.001073229,0.0002009215,0.000005762105,0.000006508246,0.00003719756,0.00004207313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3029105,"threshold_uncertainty_score":0.7041872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04733000762125181,"score_gpt":0.2917170333221051,"score_spread":0.2443870257008533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}