{"id":"W3088359649","doi":"10.3389/fgene.2020.538600","title":"Genomic Heritability and Genome-Wide Association Studies of Plasma Metabolites in Crossbred Beef Cattle","year":2020,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Genetic and phenotypic traits in livestock","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Ministry of Agriculture and Forestry; University of Alberta","funders":"Alberta Innovates; Alberta Livestock and Meat Agency; University of Alberta","keywords":"Heritability; Biology; Single-nucleotide polymorphism; Metabolome; Genetics; Metabolomics; SNP; Genetic variation; Genetic association; Genome-wide association study; In silico; Candidate gene; SNP array; Gene; Genotype; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002031024,0.000148013,0.000314904,0.00004078489,0.00002668458,0.000009568419,0.0001577726,0.0001530817,0.000002702176],"category_scores_gemma":[0.0006483006,0.0001612818,0.00004425139,0.0001238778,0.0001421889,0.000002787823,0.0001367502,0.0001006678,7.523288e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004206265,"about_ca_system_score_gemma":0.00007590041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008195112,"about_ca_topic_score_gemma":0.00004605869,"domain_scores_codex":[0.9988666,0.000094877,0.0003621631,0.0003391826,0.0001070075,0.0002302226],"domain_scores_gemma":[0.9995054,0.00005440615,0.0001218612,0.0001772818,0.00007422769,0.00006680393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007984045,0.00004523947,0.9665131,0.0000750491,0.00008905971,2.84294e-7,0.001669253,0.002845956,0.02686029,0.00001893132,0.0007358865,0.001067135],"study_design_scores_gemma":[0.0008054231,0.0001898086,0.9721844,0.000006474211,0.00002832373,3.273341e-7,0.001233484,0.00008997429,0.02060766,0.001132431,0.003545151,0.0001765878],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736187,0.0241261,0.001301831,0.0003211674,0.0002679859,0.0002343185,0.00004394577,0.000004492667,0.00008147555],"genre_scores_gemma":[0.9352856,0.001514093,0.06275422,0.0002305067,0.0001011387,0.00001488606,0.00002247209,0.00001664198,0.0000604587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06145239,"threshold_uncertainty_score":0.6576883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426328072552021,"score_gpt":0.2388559945502642,"score_spread":0.2245927138247439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}