{"id":"W3088365751","doi":"10.1101/2020.09.24.311498","title":"Human marginal zone B cell development from early T2 progenitors","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Medical Research Council; Vetenskapsrådet; National Institute for Health and Care Research","keywords":"Marginal zone; Biology; Bone marrow; Immunology; B cell; Progenitor cell; Homing (biology); Haematopoiesis; Stem cell; Cell biology; Receptor; Molecular biology; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135584,0.000135144,0.00008972613,0.0002870313,0.0001503379,0.000300048,0.00008701879,0.0001232672,0.002851004],"category_scores_gemma":[0.0001345909,0.0000905969,0.0001319393,0.0001583583,0.0001041841,0.00007508414,0.0001807154,0.000242604,0.001472903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000850605,"about_ca_system_score_gemma":0.0001308824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000437,"about_ca_topic_score_gemma":0.0005143959,"domain_scores_codex":[0.9999495,0.000008790499,0.000003343358,0.00001331609,0.00001189645,0.0000131878],"domain_scores_gemma":[0.9999571,0.00001073805,0.000004877764,0.000007337106,0.00000698952,0.00001295066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005655424,0.00001453221,0.003226463,0.00004516756,0.000008039546,0.0001626069,0.00009726352,0.0000647312,0.9907565,0.0001513714,0.0001980308,0.004709947],"study_design_scores_gemma":[0.00007637663,0.0008964816,0.1066334,0.00002428862,0.0000396213,0.002348256,0.0002632832,0.0008976836,0.8648791,0.0003828046,0.02354407,0.00001454012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988357,0.00282037,0.003447531,0.00004333793,0.00001435285,0.00004002412,0.001875259,0.0001169406,0.003285115],"genre_scores_gemma":[0.9886822,0.0008843576,0.001771244,0.00004121879,0.00001220973,0.00004398443,0.004643306,0.00002406212,0.003897404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002851004,"threshold_uncertainty_score":0.009537578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513883733705575,"score_gpt":0.2037323172970882,"score_spread":0.1885934799600325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}