{"id":"W3088445873","doi":"10.1016/j.annonc.2020.08.651","title":"537MO First-in-human study of JNJ-64619178, a protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced cancers","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Neutropenia; Cmax; Adverse effect; Anemia; Internal medicine; Pharmacodynamics; Gastroenterology; Pharmacokinetics; Dosing; Nausea; Protein arginine methyltransferase 5; Dysgeusia; Oncology; Toxicity; Pharmacology; Methyltransferase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001487002,0.0001594871,0.0003980021,0.0001032137,0.00002027755,0.000001543625,0.0001394939,0.000167215,0.00001542039],"category_scores_gemma":[0.00005304129,0.0001558067,0.00004822636,0.0003134233,0.00008006305,0.000008563637,0.00004478711,0.0001366942,4.935454e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000499098,"about_ca_system_score_gemma":0.0002200388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004367621,"about_ca_topic_score_gemma":0.005556995,"domain_scores_codex":[0.9986417,0.0001220307,0.0004755812,0.0003686703,0.0001647786,0.0002272191],"domain_scores_gemma":[0.9993215,0.0000133599,0.0002076276,0.0002104969,0.0001751742,0.00007184155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01283882,0.004441752,0.2523314,0.000286605,0.0003926225,0.0000247131,0.00419631,0.05061388,0.6468298,0.00003601324,0.0005232195,0.02748482],"study_design_scores_gemma":[0.02366146,0.067792,0.2374801,0.0001705672,0.00004889887,8.424431e-7,0.0007619775,0.0001147678,0.6629984,0.00003446043,0.006438002,0.0004984388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977049,0.0002261295,0.0000234659,0.000673063,0.00004040328,0.001138588,0.00002004424,0.000005224479,0.0001681566],"genre_scores_gemma":[0.9994692,0.00004270193,0.0001165831,0.0001298359,0.00005007503,0.0001002636,0.00005717489,0.00002138496,0.00001273571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06335025,"threshold_uncertainty_score":0.6353613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01978827361500933,"score_gpt":0.3034656153079963,"score_spread":0.283677341692987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}