{"id":"W3088534216","doi":"10.1016/j.annonc.2020.08.1166","title":"1046P Outcomes of patients with solid tumour malignancies treated with first-line (1L) immuno-oncology (IO) agents who do not meet eligibility criteria for clinical trials","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; University of Alberta; University of Calgary","funders":"","keywords":"Medicine; Internal medicine; Renal cell carcinoma; Oncology; Nivolumab; Population; Clinical trial; Melanoma; Cancer; Gastroenterology; Immunotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006756146,0.0001544367,0.0005460282,0.0003405637,0.0003614517,0.001087,0.0002638177,0.0005994542,0.005371908],"category_scores_gemma":[0.002462518,0.00009433254,0.0009862906,0.0006394175,0.0003064291,0.0007780741,0.0004330187,0.0008697051,0.0007212077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007041563,"about_ca_system_score_gemma":0.0004579654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001096015,"about_ca_topic_score_gemma":0.001905644,"domain_scores_codex":[0.9995192,0.0001313287,0.00004642954,0.00008745115,0.00007481869,0.0001406443],"domain_scores_gemma":[0.9985304,0.0003785081,0.0005914823,0.00007429467,0.0001215061,0.0003037376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02812348,0.001098754,0.8537116,0.0003945753,0.001265779,0.0006252415,0.0001591916,0.001650802,0.001995545,0.001242618,0.01467881,0.09505346],"study_design_scores_gemma":[0.002731169,0.00814423,0.9693633,0.000123913,0.001005542,0.0008975849,0.0002510524,0.001587378,0.000927511,0.002169694,0.01276717,0.00003143929],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760665,0.002582384,0.00029332,0.002018975,0.0001676111,0.0001113479,0.006952178,0.00002105399,0.01178675],"genre_scores_gemma":[0.9895639,0.0005974074,0.00008984253,0.0007502019,0.0001449893,0.00009399626,0.006780331,0.000008532195,0.001970859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005371908,"threshold_uncertainty_score":0.0179708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1754265286605803,"score_gpt":0.4738061029199914,"score_spread":0.2983795742594111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}