{"id":"W3088534458","doi":"10.1007/s12325-020-01497-6","title":"PSO-LONG: Design of a Novel, 12-Month Clinical Trial of Topical, Proactive Maintenance with Twice-Weekly Cal/BD Foam in Psoriasis","year":2020,"lang":"en","type":"article","venue":"Advances in Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Manchester Biomedical Research Centre; LEO Pharma; Regeneron Pharmaceuticals; Sun Pharma; Dermira; National Institute for Health and Care Research; Celgene; Valeant Pharmaceuticals International; Sanofi; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Calcipotriol; Betamethasone dipropionate; Psoriasis; Discontinuation; Adverse effect; Randomized controlled trial; Maintenance therapy; Clinical trial; Internal medicine; Dermatology; Surgery; Chemotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00348566,0.002066215,0.002695456,0.0005679473,0.0006656782,0.001551543,0.001182991,0.002612779,0.00882789],"category_scores_gemma":[0.001910366,0.0008687033,0.001437029,0.0003726599,0.001662619,0.001847423,0.000874726,0.003097539,0.001897696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000888639,"about_ca_system_score_gemma":0.002037736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006079713,"about_ca_topic_score_gemma":0.001317038,"domain_scores_codex":[0.9985796,0.0006543309,0.00009263718,0.0002996194,0.00009389243,0.0002798772],"domain_scores_gemma":[0.9988036,0.0002019852,0.0002299454,0.0001446412,0.0001088723,0.0005110453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9354115,0.04491218,0.0003916434,0.0003238352,0.0003083214,0.00004421175,0.0000848128,0.00031254,0.005541233,0.000167916,0.0005619377,0.01193995],"study_design_scores_gemma":[0.7168602,0.2803114,0.0009136811,0.00001843301,0.0001705996,0.00002629115,0.00002216366,0.0003218597,0.0003933466,0.0001594422,0.0007864328,0.00001619474],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9614171,0.001626684,0.001634404,0.0007710283,0.0008051845,0.02917876,0.0009722119,0.000191543,0.00340316],"genre_scores_gemma":[0.925404,0.001320821,0.007063861,0.001660133,0.0009147329,0.05474709,0.001243884,0.00005248054,0.007593073],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.00882789,"threshold_uncertainty_score":0.02953225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07843577025216758,"score_gpt":0.3296592851494617,"score_spread":0.2512235148972942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}