{"id":"W3088534458","doi":"10.1007/s12325-020-01497-6","title":"PSO-LONG: Design of a Novel, 12-Month Clinical Trial of Topical, Proactive Maintenance with Twice-Weekly Cal/BD Foam in Psoriasis","year":2020,"lang":"en","type":"article","venue":"Advances in Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Manchester Biomedical Research Centre; LEO Pharma; Regeneron Pharmaceuticals; Sun Pharma; Dermira; National Institute for Health and Care Research; Celgene; Valeant Pharmaceuticals International; Sanofi; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Calcipotriol; Betamethasone dipropionate; Psoriasis; Discontinuation; Adverse effect; Randomized controlled trial; Maintenance therapy; Clinical trial; Internal medicine; Dermatology; Surgery; Chemotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003462822,0.0002224228,0.0007278002,0.00007259533,0.0000278701,0.000003244515,0.0002731522,0.0002317673,0.00005226018],"category_scores_gemma":[0.0001648724,0.0001594515,0.0001209304,0.0002831985,0.0003191518,0.0001664308,0.00002674402,0.0002341298,0.000003892066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003528841,"about_ca_system_score_gemma":0.0001160374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005487786,"about_ca_topic_score_gemma":0.0001490994,"domain_scores_codex":[0.9980986,0.000432289,0.0006916559,0.0004194487,0.00006523268,0.0002927741],"domain_scores_gemma":[0.9986513,0.0006784508,0.0003333226,0.0002506422,0.00005700395,0.00002923556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4486984,0.005166474,0.06514077,0.00004371663,0.0008257539,0.00004242836,0.003902114,0.0004293921,0.0262183,0.0006631735,0.00008363868,0.4487858],"study_design_scores_gemma":[0.5786313,0.06823794,0.0886328,0.0004523891,0.0002751599,0.00003094524,0.002916839,0.0001352847,0.2377574,0.001025214,0.0206264,0.001278309],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840848,0.00743173,0.005699366,0.0002947848,0.0005376243,0.001457538,0.00003004117,0.00002672163,0.0004374276],"genre_scores_gemma":[0.9896911,0.006655772,0.003139119,0.0001379101,0.00007886595,0.0001649165,0.00001493263,0.00002005057,0.00009732095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4475075,"threshold_uncertainty_score":0.6502244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07843577025216758,"score_gpt":0.3296592851494617,"score_spread":0.2512235148972942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}