{"id":"W3088538599","doi":"10.3389/fmed.2020.549860","title":"Direct Clinical Evidence Recommending the Use of Proteinase K or Dithiothreitol to Pretreat Sputum for Detection of SARS-CoV-2","year":2020,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"National Mega Project on Major Infectious Disease Prevention","keywords":"Dithiothreitol; Sputum; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Virology; Medicine; Chemistry; Internal medicine; Enzyme; Biochemistry; Pathology; Tuberculosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.001613247,0.000193551,0.0009592245,0.0002569431,0.00005258236,0.00000816907,0.0002809819,0.0001452894,0.000005097749],"category_scores_gemma":[0.01794985,0.000113958,0.0001452723,0.0009307882,0.0003213559,0.0001352461,0.00009026087,0.0004002354,0.000002153586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001229392,"about_ca_system_score_gemma":0.0001950457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003000481,"about_ca_topic_score_gemma":0.00008243507,"domain_scores_codex":[0.9975291,0.0002502578,0.000898657,0.0004453895,0.0005490238,0.0003275748],"domain_scores_gemma":[0.9976563,0.001340856,0.0002302585,0.000472711,0.0002236229,0.0000761998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02686051,0.0003009837,0.2483688,0.001980376,0.0003222357,0.00009202179,0.002891611,0.000003481782,0.4782571,0.000008846868,0.09170086,0.1492131],"study_design_scores_gemma":[0.004230428,0.009207394,0.005760367,0.002984086,0.0002601789,0.00001201289,0.0006648796,0.005872746,0.8109365,0.0000480476,0.1598376,0.0001857221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8621285,0.001611455,0.1110486,0.01753035,0.001506756,0.005911551,0.00001844586,0.00006966331,0.0001746885],"genre_scores_gemma":[0.9499434,0.0001279807,0.01458727,0.03389721,0.0009820267,0.0003559857,0.00000271769,0.00005416174,0.00004930759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3326794,"threshold_uncertainty_score":0.9903224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3052264706878599,"score_gpt":0.4561794376037406,"score_spread":0.1509529669158807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}