{"id":"W3088564351","doi":"10.1016/j.annonc.2020.08.533","title":"422P Age and pathological complete response after neoadjuvant chemoradiation (CRT) with or without oxaliplatin in locally advanced rectal cancer (LARC): Individual patient data (IPD) meta-analysis of three randomised trials (RTs)","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Daiichi Sankyo Company; Sierra Oncology; Foundation Medicine; Chugai Pharmaceutical; Novartis Pharma; Genentech; Eli Lilly and Company; Ono Pharmaceutical; Daiichi Sankyo Europe; Servier; European Society for Medical Oncology; Novo Nordisk; Danmarks Frie Forskningsfond; Daiichi-Sankyo; GlaxoSmithKline Japan; Sanofi; Les Laboratories Pierre Fabre; Strategiske Forskningsråd; FibroGen; BeiGene; Natera; Sanofi K.K.; INCLIVA Instituto de Investigación Sanitaria; GlaxoSmithKline; AstraZeneca","keywords":"Medicine; Oxaliplatin; Clinical endpoint; Colorectal cancer; Odds ratio; Internal medicine; Surgery; Confounding; Randomized controlled trial; Gastroenterology; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01115997,0.00326651,0.00917951,0.001473622,0.0005433203,0.003035514,0.001445681,0.002708539,0.008367529],"category_scores_gemma":[0.01997374,0.001710307,0.05464277,0.001727317,0.00107906,0.001825624,0.001598499,0.003979101,0.0007474255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001165388,"about_ca_system_score_gemma":0.001059089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004805229,"about_ca_topic_score_gemma":0.008463996,"domain_scores_codex":[0.9888662,0.007713807,0.001299549,0.00127654,0.0004943708,0.0003496088],"domain_scores_gemma":[0.991019,0.006390409,0.001250072,0.0007689208,0.0003290758,0.0002424772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.05161424,0.00004380098,0.004188373,0.02741246,0.9107935,0.00008060106,0.00004997718,0.000740623,0.000526732,0.0001211975,0.0005305408,0.003897875],"study_design_scores_gemma":[0.02094171,0.001072133,0.004391284,0.001039855,0.9704245,0.00007228581,0.00003373656,0.000366732,0.0001752221,0.0003152501,0.001137156,0.00003022799],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2109513,0.7634759,0.009062869,0.001459947,0.002951644,0.001721557,0.006134168,0.0004782197,0.003764493],"genre_scores_gemma":[0.9461822,0.04368204,0.002920287,0.001637641,0.0005031664,0.001071861,0.001591393,0.000103043,0.002308457],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01115997,"threshold_uncertainty_score":0.05902028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5041576845492349,"score_gpt":0.4553447199322874,"score_spread":0.04881296461694751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}