{"id":"W3088605758","doi":"10.1093/ofid/ofaa450","title":"Genetic Determinants of Antibody-Mediated Immune Responses to Infectious Diseases Agents: A Genome-Wide and HLA Association Study","year":2020,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Medical Research Council; National Institute for Health and Care Research; Jewish General Hospital; European Commission; King's College London; Canadian Institutes of Health Research; National Institutes of Health; Cancer Research UK; National Human Genome Research Institute; Wellcome Trust; GlaxoSmithKline","keywords":"Human leukocyte antigen; Medicine; Genome-wide association study; Immune system; Immunology; Antibody; Genetics; Single-nucleotide polymorphism; Virology; Biology; Antigen; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001332354,0.0004082882,0.0009554937,0.0002777335,0.000334178,0.0001849873,0.0002753054,0.0001365112,0.000207785],"category_scores_gemma":[0.003197499,0.0003637387,0.0002290925,0.0007533856,0.00009246465,0.0003045564,0.0005863309,0.0001725915,0.0001095562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001899011,"about_ca_system_score_gemma":0.0003782693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008077532,"about_ca_topic_score_gemma":0.00009615843,"domain_scores_codex":[0.9972224,0.0002874053,0.0007587071,0.000657017,0.0005078611,0.0005666266],"domain_scores_gemma":[0.9974,0.0003990021,0.0004372557,0.0004449356,0.0002425848,0.001076212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001372485,0.002614873,0.9914445,0.0001588657,0.0005886962,0.0002689731,0.000421534,0.00003456339,0.0007091369,0.000003948463,0.0009312949,0.001451105],"study_design_scores_gemma":[0.00536839,0.003233593,0.9875389,0.0001565672,0.001539404,0.00001813709,0.0005468947,0.0001191737,0.00009082843,0.00006500188,0.0009266237,0.000396528],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918133,0.002772911,0.00001719753,0.0005531315,0.0001679413,0.003039239,0.000742132,0.0002091429,0.0006850228],"genre_scores_gemma":[0.9966591,0.0005314943,0.00001078013,0.002047193,0.00008067679,0.0002094122,0.000118698,0.00007644114,0.0002662215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0048458,"threshold_uncertainty_score":0.9998814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269997916833354,"score_gpt":0.3041556253514921,"score_spread":0.2914556461831586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}