{"id":"W3088605758","doi":"10.1093/ofid/ofaa450","title":"Genetic Determinants of Antibody-Mediated Immune Responses to Infectious Diseases Agents: A Genome-Wide and HLA Association Study","year":2020,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Medical Research Council; National Institute for Health and Care Research; Jewish General Hospital; European Commission; King's College London; Canadian Institutes of Health Research; National Institutes of Health; Cancer Research UK; National Human Genome Research Institute; Wellcome Trust; GlaxoSmithKline","keywords":"Human leukocyte antigen; Medicine; Genome-wide association study; Immune system; Immunology; Antibody; Genetics; Single-nucleotide polymorphism; Virology; Biology; Antigen; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001744225,0.0004865227,0.0004471826,0.0008053554,0.000504486,0.0008577601,0.0005254476,0.0008675163,0.003242223],"category_scores_gemma":[0.002487188,0.0003616119,0.0008996615,0.00251224,0.0004081009,0.0003745902,0.0008349228,0.0008900825,0.0003548925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001945603,"about_ca_system_score_gemma":0.0002575107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003081797,"about_ca_topic_score_gemma":0.003306111,"domain_scores_codex":[0.9986705,0.0004647197,0.0001350879,0.0004589973,0.0001267941,0.0001438797],"domain_scores_gemma":[0.9981604,0.0006282699,0.0005171944,0.000277915,0.0001503206,0.0002659129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004339903,0.00003999818,0.9943721,0.00004382964,0.0006860286,0.0002978822,0.00009083541,0.0001554262,0.001648739,0.00006662674,0.0002581207,0.001906454],"study_design_scores_gemma":[0.00003096215,0.00009253266,0.9982961,0.00001291937,0.0002902987,0.0003844357,0.00005814473,0.0003103651,0.0001028763,0.00004956489,0.0003662002,0.000005627522],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968095,0.0007004162,0.0006906109,0.00009188837,0.00001090885,0.00001382128,0.001370791,0.000008863028,0.0003030499],"genre_scores_gemma":[0.9979308,0.0001943799,0.0006414318,0.00004644859,0.00001655127,0.00001731524,0.0009546816,0.000006706574,0.0001917576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003242223,"threshold_uncertainty_score":0.01084632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269997916833354,"score_gpt":0.3041556253514921,"score_spread":0.2914556461831586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}