{"id":"W3088629207","doi":"10.1074/jbc.ac120.015720","title":"Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"RNA polymerase; RNA; RNA-dependent RNA polymerase; Mutation; Polymerase; DNA; Virology; Coronavirus; Biology; Genetics; Coronavirus disease 2019 (COVID-19); Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005222222,0.0001782049,0.0006136116,0.00004468352,0.00003322571,0.00001104268,0.0001748463,0.0003313258,0.0004093779],"category_scores_gemma":[0.0004227188,0.000128575,0.0002555645,0.0001507979,0.0001070413,0.00007987527,0.00008360786,0.0006460013,0.000006742268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249132,"about_ca_system_score_gemma":0.0001675278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001521211,"about_ca_topic_score_gemma":5.574772e-7,"domain_scores_codex":[0.9979686,0.00007818409,0.0008795673,0.0002347331,0.0006083344,0.0002305687],"domain_scores_gemma":[0.9985307,0.0001302226,0.0007600043,0.0001582913,0.0002697624,0.0001509634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001964602,0.0003039072,0.001214152,0.000335145,0.0001056094,0.000230631,0.00005283923,2.491427e-7,0.9937852,0.000006356408,0.0004072171,0.001594109],"study_design_scores_gemma":[0.002008877,0.001133549,0.0002777017,0.0001582658,0.00004637845,0.000320582,0.000288608,0.00001138893,0.994671,0.0002641772,0.0007064893,0.0001129537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971911,0.0008619346,0.0002941075,0.0004408639,0.00005107323,0.0001421583,0.00006932701,0.00001437958,0.0009350018],"genre_scores_gemma":[0.9963104,0.00008067665,0.00008443632,0.003210879,0.0002407108,0.000003598703,0.00000729518,0.00001324502,0.00004873741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002770016,"threshold_uncertainty_score":0.5243137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08734317370029991,"score_gpt":0.3467248041400832,"score_spread":0.2593816304397833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}