{"id":"W3088639284","doi":"10.1038/s42003-020-01253-0","title":"Highly efficient gene transfer in the mouse gut microbiota is enabled by the Incl2 conjugative plasmid TP114","year":2020,"lang":"en","type":"article","venue":"Communications Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Université de Sherbrooke; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Compute Canada","keywords":"Plasmid; Horizontal gene transfer; Biology; Microbiome; Genetics; Bacteria; Gene; Pilus; Bacterial conjugation; Gene transfer; Microbiology; Bacterial genetics; Genome; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861262,0.0001330352,0.0001237209,0.00001982594,0.0001601081,0.00001614187,0.001223208,0.0001283406,0.00001501651],"category_scores_gemma":[0.00005152574,0.00008792514,0.0000627077,0.0001598695,0.0002701974,0.00000112126,0.000279551,0.0002130671,0.0000168777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009900571,"about_ca_system_score_gemma":0.00003219882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003686834,"about_ca_topic_score_gemma":0.00004984086,"domain_scores_codex":[0.9990829,0.0002490926,0.0002148646,0.0002212882,0.00003707616,0.0001947742],"domain_scores_gemma":[0.998782,0.00008865952,0.00002676216,0.001023812,0.00004212275,0.00003669226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001902637,0.00005550409,0.0001494972,0.000003724846,0.00003325874,1.459932e-7,0.001660773,0.000209497,0.9917563,0.0003243361,0.005549757,0.0002381944],"study_design_scores_gemma":[0.0006661937,0.000171083,0.0003530645,0.000003484389,0.00002208034,0.000008686232,0.0007303292,0.001675326,0.6693237,0.00002278679,0.3268293,0.0001939963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9541578,0.007612623,0.008214025,0.02831257,0.00004566141,0.0005078925,0.0002641441,0.00001863505,0.000866688],"genre_scores_gemma":[0.9933351,0.001044142,0.0003755548,0.004610495,0.00003666362,0.00007379481,0.0004521133,0.00001291036,0.00005926673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3224326,"threshold_uncertainty_score":0.3585483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699296501792371,"score_gpt":0.3042261348769247,"score_spread":0.287233169859001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}