{"id":"W3088668630","doi":"10.1002/1873-3468.13938","title":"Picky ABCG5/G8 and promiscuous ABCG2 ‐ a tale of fatty diets and drug toxicity","year":2020,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Biotechnology and Biological Sciences Research Council; Austrian Science Fund; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"ATP-binding cassette transporter; Context (archaeology); Abcg2; Sterol regulatory element-binding protein; Biochemistry; Binding site; Biology; Transporter; Transmembrane domain; Chemistry; Sterol; Cholesterol; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003000239,0.0005105077,0.0006459635,0.001354731,0.0002176837,0.0006491031,0.0005051115,0.0008591572,0.00220153],"category_scores_gemma":[0.0003390583,0.0001742429,0.0002944213,0.0009945044,0.0005155283,0.001001782,0.0004952859,0.001479912,0.001625667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005444441,"about_ca_system_score_gemma":0.0005408605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005271211,"about_ca_topic_score_gemma":0.0009879101,"domain_scores_codex":[0.9998906,0.00001783481,0.00001588854,0.00002034844,0.00004185586,0.00001359339],"domain_scores_gemma":[0.999922,0.00003198699,0.0000117487,0.000004296869,0.00001960686,0.00001037515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000159358,0.00005067506,0.0002486296,0.01151723,0.0001255694,0.0008159111,0.0001016248,0.0003695928,0.008601977,0.01833555,0.04822255,0.9114512],"study_design_scores_gemma":[0.00001360701,0.00005100726,0.0007481964,0.001006505,0.00004780952,0.002451996,0.00004084707,0.00007215202,0.001455368,0.003461551,0.9906375,0.00001341603],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004262514,0.9962483,0.0002426415,0.000656004,0.0003409852,0.000004242236,0.00001703239,0.00001461549,0.002049905],"genre_scores_gemma":[0.003163761,0.992614,0.0003337905,0.0007891033,0.0003011063,0.000008394334,0.00005043916,0.000003944007,0.00273542],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00220153,"threshold_uncertainty_score":0.007364869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175493396164148,"score_gpt":0.2663657081156527,"score_spread":0.2488163684992379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}