{"id":"W3088668630","doi":"10.1002/1873-3468.13938","title":"Picky ABCG5/G8 and promiscuous ABCG2 ‐ a tale of fatty diets and drug toxicity","year":2020,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Biotechnology and Biological Sciences Research Council; Austrian Science Fund; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"ATP-binding cassette transporter; Context (archaeology); Abcg2; Sterol regulatory element-binding protein; Biochemistry; Binding site; Biology; Transporter; Transmembrane domain; Chemistry; Sterol; Cholesterol; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001594332,0.0004395062,0.002013466,0.0001137299,0.00005884547,0.00001960062,0.0001255578,0.0001874902,0.00004316827],"category_scores_gemma":[0.00002084518,0.0003185798,0.0003177424,0.0001754065,0.0001957277,0.00004583013,0.00005353254,0.0004437898,0.000008872728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004491232,"about_ca_system_score_gemma":0.0001008501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001679054,"about_ca_topic_score_gemma":0.00001606207,"domain_scores_codex":[0.9982643,0.00005391903,0.0005411935,0.000548335,0.0002970578,0.0002951622],"domain_scores_gemma":[0.9991117,0.00005358413,0.0002613921,0.000310417,0.00002458329,0.0002382911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001615296,0.000180576,0.0002583383,0.1478211,0.0008460017,0.001371545,0.0014208,1.279017e-7,0.00224839,0.0001039862,0.004496344,0.8410913],"study_design_scores_gemma":[0.0008585239,0.000120331,0.0003407524,0.01213717,0.001560622,0.0001397404,0.00005075667,0.000001850654,0.0002639187,0.00001486739,0.984099,0.0004124585],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006407395,0.989032,0.0001459535,0.002357504,0.0002011325,0.001362504,0.0001358965,0.00006457161,0.0002929968],"genre_scores_gemma":[0.00112057,0.9958357,0.0009457545,0.001054513,0.0002122496,0.00003773169,0.00008039403,0.00007203782,0.0006410684],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9796027,"threshold_uncertainty_score":0.9999266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175493396164148,"score_gpt":0.2663657081156527,"score_spread":0.2488163684992379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}