{"id":"W3088684406","doi":"10.3390/v12101104","title":"Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S Glycoproteins","year":2020,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Mitacs; Fondation du CHUM","keywords":"Glycoprotein; Coronavirus; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Cooperativity; Spike (software development); Viral entry; Plasma protein binding; Receptor; Angiotensin-converting enzyme 2; Cooperative binding; Virology; Coronavirus disease 2019 (COVID-19); Chemistry; Biophysics; Binding site; Virus; Biology; Biochemistry; Medicine; Viral replication; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002063886,0.0002149457,0.000225706,0.00009018274,0.0001879735,0.0002168668,0.0002242438,0.000164336,0.001618553],"category_scores_gemma":[0.0003292224,0.00009952805,0.0002556223,0.0000856137,0.0001800845,0.0001758851,0.0001566606,0.0003112018,0.0002207118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003185093,"about_ca_system_score_gemma":0.0001798473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120138,"about_ca_topic_score_gemma":0.001348667,"domain_scores_codex":[0.9997873,0.00005033338,0.000008837064,0.00004419586,0.0000574669,0.00005200701],"domain_scores_gemma":[0.9998922,0.00003009576,0.00002428037,0.00001148693,0.000015144,0.00002669481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004312486,0.0001165128,0.003297426,0.00004292518,0.00004160304,0.00008712804,0.00004774413,0.0006235774,0.9932871,0.0003207473,0.0002119048,0.001492068],"study_design_scores_gemma":[0.00004148335,0.0005837742,0.03073939,0.000008293347,0.00003330999,0.0004875588,0.0001078874,0.01951543,0.945618,0.0001756632,0.002670311,0.00001896131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982036,0.0004040725,0.0006911512,0.00004266957,0.00001367835,0.000005280123,0.00005388581,0.00001031733,0.0005753565],"genre_scores_gemma":[0.9986004,0.0001535471,0.0005074528,0.00004456121,0.000005800434,0.000004431813,0.0001448701,0.000004897605,0.0005339558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618553,"threshold_uncertainty_score":0.005414665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1301165298658629,"score_gpt":0.4065847681056129,"score_spread":0.2764682382397501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}