{"id":"W3088690536","doi":"10.1021/acsomega.0c03303","title":"Improvement of DNA Vector Delivery of DOTAP Lipoplexes by Short-Chain Aminolipids","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Novartis Stiftung für Medizinisch-Biologische Forschung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Gene delivery; Genetic enhancement; Transfection; Chemistry; In vivo; DNA; Cytotoxicity; Transgene; Vector (molecular biology); Gene; Molecular biology; Biochemistry; Pharmacology; In vitro; Biology; Biotechnology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005851468,0.0001354877,0.0002000611,0.00002107717,0.00001825794,0.000006747917,0.0002511139,0.0001057269,0.00001163133],"category_scores_gemma":[0.00003496967,0.0001285649,0.0001013533,0.00008149386,0.00007176289,0.000004621656,0.0001491494,0.00005585027,0.000005785497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006318133,"about_ca_system_score_gemma":0.00004204252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005383242,"about_ca_topic_score_gemma":0.00001199821,"domain_scores_codex":[0.9991259,0.0000168594,0.000286742,0.0002616353,0.0001355165,0.0001733415],"domain_scores_gemma":[0.9994689,0.0000088632,0.00008661747,0.0002542035,0.0001046082,0.00007679426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001013661,0.00005970307,0.001347643,0.0000470534,0.00008579902,8.729104e-7,0.00008026512,0.00000645727,0.9817,0.00001263462,0.01169045,0.004867759],"study_design_scores_gemma":[0.0002434824,0.001266906,0.0006938193,0.00001231077,0.00002182688,7.702412e-7,0.0001184811,0.00001790222,0.9906296,0.000007478237,0.006854581,0.0001329157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979361,0.001106306,0.0001473029,0.0001788183,0.00009435101,0.0001178107,0.0001200957,0.000007123974,0.0002921156],"genre_scores_gemma":[0.9984491,0.0004990227,0.00006632971,0.0004818849,0.0001536135,0.00001052848,0.0001131885,0.00001517998,0.0002111725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008929534,"threshold_uncertainty_score":0.5242726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01327749412874393,"score_gpt":0.228230264916142,"score_spread":0.2149527707873981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}