{"id":"W3088690536","doi":"10.1021/acsomega.0c03303","title":"Improvement of DNA Vector Delivery of DOTAP Lipoplexes by Short-Chain Aminolipids","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Novartis Stiftung für Medizinisch-Biologische Forschung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Gene delivery; Genetic enhancement; Transfection; Chemistry; In vivo; DNA; Cytotoxicity; Transgene; Vector (molecular biology); Gene; Molecular biology; Biochemistry; Pharmacology; In vitro; Biology; Biotechnology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003682841,0.0005386783,0.0002331316,0.0003322148,0.000217813,0.0002674517,0.0003419251,0.0005313516,0.0009195107],"category_scores_gemma":[0.0001806241,0.0002520247,0.0003538061,0.0001716581,0.0002747914,0.0004436315,0.0003128275,0.0006539009,0.0004394175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005018909,"about_ca_system_score_gemma":0.0005659412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002246025,"about_ca_topic_score_gemma":0.00286305,"domain_scores_codex":[0.9998214,0.00002395629,0.00001952892,0.00004293093,0.00006011294,0.00003216135],"domain_scores_gemma":[0.999897,0.00001778938,0.00003220307,0.00001076384,0.00002066669,0.00002162424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001662202,0.000006295052,0.00001888169,0.00001976604,0.000001490795,0.00002940245,0.000007542774,0.00003120671,0.9992846,0.0001000588,0.00001535163,0.0004687258],"study_design_scores_gemma":[0.000007316808,0.00007879885,0.0002793009,0.000003187405,0.000009330909,0.00007103101,0.000006361076,0.0003583296,0.9978852,0.00001943785,0.001278161,0.000003630157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9394119,0.002341979,0.05210416,0.0004534669,0.0001509765,0.0003434551,0.001044925,0.0005177893,0.00363142],"genre_scores_gemma":[0.9401008,0.003470964,0.04031308,0.00006914338,0.00001554632,0.0002726151,0.001192413,0.0001803406,0.01438519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002246025,"threshold_uncertainty_score":0.004465878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01327749412874393,"score_gpt":0.228230264916142,"score_spread":0.2149527707873981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}