{"id":"W3088710714","doi":"10.1038/s41467-020-18649-5","title":"Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; Canadian Science Centre for Human and Animal Health; Lawson Health Research Institute; Western University","funders":"Janssen Pharmaceuticals; National Research Council Canada; W. Garfield Weston Foundation; Government of Canada; Canadian Urological Oncology Group","keywords":"Akkermansia muciniphila; Prostate cancer; Androgen; Cancer research; Biology; Prostate; Abiraterone acetate; Cancer; Internal medicine; Medicine; Endocrinology; Gut flora; Immunology; Androgen deprivation therapy; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007589427,0.0001803828,0.0002951878,0.0004431944,0.0003514604,0.0004604062,0.00009999981,0.0001632311,0.001702054],"category_scores_gemma":[0.0003263057,0.0001090391,0.0001808594,0.0003564833,0.0001362799,0.0001416657,0.000239188,0.0002915632,0.0001809532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00016848,"about_ca_system_score_gemma":0.0002289383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002790847,"about_ca_topic_score_gemma":0.003818698,"domain_scores_codex":[0.9998678,0.00002637984,0.00001023937,0.00002902956,0.00003676298,0.00002987162],"domain_scores_gemma":[0.999846,0.00001731305,0.0000437338,0.000007503099,0.00001686677,0.00006856619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004400319,0.0002407508,0.3228485,0.0003033835,0.0001179941,0.001600282,0.000639639,0.0002212418,0.6220685,0.0001004201,0.0007016954,0.04675734],"study_design_scores_gemma":[0.00004633847,0.001723128,0.9506343,0.00004581805,0.0001471829,0.005115813,0.001009951,0.000614229,0.03583701,0.0001228889,0.004679152,0.00002420745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972841,0.001620186,0.0001567681,0.00006660731,0.00001068911,0.00001210813,0.0002618218,0.00001586645,0.000571819],"genre_scores_gemma":[0.9987018,0.0004376141,0.0001885845,0.00005057526,0.000009335385,0.000005531017,0.0001570845,0.000004314282,0.000445299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002790847,"threshold_uncertainty_score":0.005693913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02856158042748669,"score_gpt":0.3140438069228069,"score_spread":0.2854822264953202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}