{"id":"W3088741547","doi":"10.1016/j.annonc.2020.08.2240","title":"LBA12 PALLAS: A randomized phase III trial of adjuvant palbociclib with endocrine therapy versus endocrine therapy alone for HR+/HER2- early breast cancer","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Chugai Pharmaceutical; Samsung; Genentech; Servier; Astellas Pharma; Oncolytics Biotech; Eisai; Genomic Health; Teva Pharmaceutical Industries; Daiichi-Sankyo; PharmaMar; Celgene; G1 Therapeutics; Breast Cancer Research Foundation; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Hazard ratio; Breast cancer; Palbociclib; Internal medicine; Oncology; Adjuvant; Cancer; Interim analysis; Randomized controlled trial; Confidence interval; Metastatic breast cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001985807,0.002936614,0.003335853,0.0007643186,0.000547358,0.001774743,0.001793381,0.001970687,0.0154379],"category_scores_gemma":[0.001669638,0.001072406,0.002390066,0.0006602323,0.001984852,0.001830939,0.0007891196,0.006895569,0.003118595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001661628,"about_ca_system_score_gemma":0.001992052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002207978,"about_ca_topic_score_gemma":0.00645191,"domain_scores_codex":[0.9993075,0.000349775,0.0000239815,0.0001214281,0.00005099389,0.0001462994],"domain_scores_gemma":[0.9992626,0.000162123,0.0001272792,0.00006415046,0.00003465982,0.0003491556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9639368,0.00776259,0.0004758615,0.0005260622,0.0009547711,0.00002773496,0.00004717543,0.0006443891,0.002305466,0.0002493717,0.002361211,0.02070857],"study_design_scores_gemma":[0.9607225,0.03635124,0.000783137,0.00002455653,0.000352368,0.00002696097,0.0000261551,0.0003885645,0.0002007405,0.0002168929,0.000892568,0.00001428152],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684267,0.00759513,0.001192527,0.00335683,0.001694736,0.005179581,0.003824298,0.0005965623,0.008133765],"genre_scores_gemma":[0.9632432,0.004768037,0.002911086,0.003207026,0.000829934,0.007450393,0.004896228,0.0001490398,0.01254487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0154379,"threshold_uncertainty_score":0.05164492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1106974504715896,"score_gpt":0.4275877126066093,"score_spread":0.3168902621350197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}