{"id":"W3088767168","doi":"10.1016/j.mehy.2020.110283","title":"Intersection between sleep and neurovascular coupling as the driving pathophysiology of Alzheimer’s disease","year":2020,"lang":"en","type":"article","venue":"Medical Hypotheses","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Dementia; Pathophysiology; Neurovascular bundle; Disease; Neuroscience; Glymphatic system; Medicine; Cerebral blood flow; Mechanism (biology); Cerebrospinal fluid; Internal medicine; Pathology; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.00025651,0.0001000448,0.0001920661,0.00003744938,0.0001384693,0.00002335189,0.000312964,0.00005415491,0.0001788441],"category_scores_gemma":[0.009399557,0.00006398454,0.00007596146,0.0002094073,0.0005270512,0.00006832995,0.0002471537,0.0002955019,0.00002781163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004401083,"about_ca_system_score_gemma":0.00004714724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002175961,"about_ca_topic_score_gemma":9.312972e-7,"domain_scores_codex":[0.9984411,0.000206092,0.0001955395,0.0003271085,0.000612097,0.00021804],"domain_scores_gemma":[0.9980409,0.001353415,0.00005108697,0.0001798862,0.00002232186,0.0003523847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000492116,0.0003680571,0.09708357,0.0002898001,0.0002158659,0.0007661475,0.003422606,0.0003002664,0.2109558,0.003448436,0.0004295656,0.6822278],"study_design_scores_gemma":[0.00291478,0.001793074,0.2917176,0.0004013111,0.0006270764,0.00004756755,0.001218752,0.1904556,0.4852382,0.01571006,0.008841185,0.001034827],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933867,0.0002398979,0.0005907745,0.005377796,0.00009527035,0.0001614865,0.00000398044,0.00003929331,0.0001048282],"genre_scores_gemma":[0.9977502,0.0001302093,0.000006282262,0.00183747,0.0002404514,0.00001637928,7.347674e-7,0.00001476434,0.000003552246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6811929,"threshold_uncertainty_score":0.9989447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07337746065586825,"score_gpt":0.3056491828714407,"score_spread":0.2322717222155725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}