{"id":"W3088853028","doi":"10.3389/fonc.2020.573399","title":"Targeting Mitochondrial Singlet Oxygen Dynamics Offers New Perspectives for Effective Metabolic Therapies of Cancer","year":2020,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Fondation de France; Polytechnique Montréal","keywords":"Cancer; Radiation therapy; Mitochondrion; Cancer research; Singlet oxygen; Cancer cell; Photodynamic therapy; Warburg effect; Chemotherapy; Medicine; Cancer therapy; Cancer treatment; Bioinformatics; Biology; Chemistry; Cell biology; Internal medicine; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001990535,0.0005203183,0.00262196,0.0002237127,0.00005850942,0.00001447731,0.0004708341,0.000856129,0.00001215701],"category_scores_gemma":[0.0003812881,0.0004813293,0.0007642107,0.0002757215,0.0002320166,0.000006186955,0.000132497,0.0003583806,8.376924e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003581377,"about_ca_system_score_gemma":0.001792855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001953858,"about_ca_topic_score_gemma":0.0002564275,"domain_scores_codex":[0.997553,0.0003745579,0.0006477152,0.0008285129,0.0001286143,0.0004676015],"domain_scores_gemma":[0.9987262,0.00008360025,0.0006328553,0.0002982784,0.0001286029,0.0001303992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003938866,0.00008127445,0.00001745191,0.001292444,0.001242607,0.000001511293,0.0007555873,0.00002469274,0.00071902,0.0001123456,0.05481188,0.9405473],"study_design_scores_gemma":[0.001484954,0.0004368584,0.000008128398,0.0003003926,0.001029751,0.000004328333,0.0007579376,0.00004283542,0.0001166654,0.00009583512,0.9952885,0.0004338164],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005270099,0.9796675,0.00766607,0.0001656396,0.009610306,0.002250466,0.0004471622,0.00001349246,0.0001266301],"genre_scores_gemma":[0.00001220394,0.9781359,0.01335082,0.00007809523,0.006748602,0.0007551225,0.0003884078,0.0001041648,0.0004266654],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9404766,"threshold_uncertainty_score":0.9997638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358249398634275,"score_gpt":0.32202830150036,"score_spread":0.3084458075140172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}