{"id":"W3088872436","doi":"10.1016/j.annonc.2020.08.1225","title":"1102P Clinical benefit in BRAFV600 mutation-positive melanoma defined by programmed death ligand 1 (PD-L1) and/or lactate dehydrogenase (LDH) status: Exploratory analyses from the IMspire150 study","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada)","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Hazard ratio; Internal medicine; Vemurafenib; Lactate dehydrogenase; Gastroenterology; Oncology; Melanoma; Cancer; Confidence interval; Metastatic melanoma; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008945559,0.00077451,0.0009439709,0.0002395665,0.0001574767,0.0009211948,0.0003115539,0.0005086913,0.00219925],"category_scores_gemma":[0.0006960572,0.0002334408,0.001200563,0.0003344134,0.0003585332,0.0004900708,0.0003073968,0.001218818,0.0005387528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004663026,"about_ca_system_score_gemma":0.0003927426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000416401,"about_ca_topic_score_gemma":0.001740781,"domain_scores_codex":[0.9997241,0.0001092748,0.0000127184,0.0000680151,0.00002777738,0.00005808349],"domain_scores_gemma":[0.9997116,0.00008877137,0.00006310449,0.00002496332,0.00002001445,0.00009149534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5370858,0.003416315,0.1379358,0.001604503,0.009612841,0.00108677,0.0002181654,0.006205841,0.04192613,0.001684459,0.01327678,0.2459466],"study_design_scores_gemma":[0.1430165,0.08665995,0.7143935,0.0003651784,0.01266333,0.002412041,0.0003859316,0.004996024,0.00552768,0.005394137,0.02401131,0.0001743724],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903155,0.003476342,0.0002027348,0.0004902681,0.0000588208,0.0000813681,0.001719094,0.00004435008,0.003611556],"genre_scores_gemma":[0.9936042,0.001217343,0.0002779831,0.0004415597,0.00009304877,0.00008765957,0.003198431,0.00001886571,0.001060805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00219925,"threshold_uncertainty_score":0.00735724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1653628566374739,"score_gpt":0.4136882348580487,"score_spread":0.2483253782205748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}