{"id":"W3088887338","doi":"10.1093/narcan/zcaa028","title":"DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions","year":2020,"lang":"en","type":"article","venue":"NAR Cancer","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Biology; RNA Helicase A; Genome instability; Homologous recombination; DNA; Molecular biology; Chromatin immunoprecipitation; Chromatin; Transcription (linguistics); DNA repair; Helicase; RNA; DNA replication; DNA damage; Cell biology; Gene; Genetics; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009143261,0.000203591,0.0001872915,0.00002407606,0.0001439887,0.00002586421,0.000154543,0.0001848894,0.0001558709],"category_scores_gemma":[0.00003276895,0.0002005779,0.0001097431,0.0001216406,0.00005954864,0.000005960268,0.0002206805,0.0001045766,0.00003067786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004241554,"about_ca_system_score_gemma":0.00009903236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005036806,"about_ca_topic_score_gemma":0.0003004345,"domain_scores_codex":[0.9986629,0.00003215313,0.0001985316,0.0006194566,0.0001727744,0.0003141534],"domain_scores_gemma":[0.9992427,0.000004793689,0.00005386005,0.0003235713,0.0000733558,0.0003017259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003251535,0.00002575413,0.0004359232,0.00005223013,0.00007493525,0.00001632568,0.0002603612,0.0000289602,0.9880931,0.00003594794,0.009332771,0.001318479],"study_design_scores_gemma":[0.001007159,0.0004152421,0.00042397,0.00002839555,0.00003740686,0.00002641216,0.00002954449,0.00008593033,0.7490264,0.00001160876,0.2486664,0.0002415348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941165,0.001552853,0.0001597595,0.00233199,0.0001425889,0.00046641,0.0001207216,0.0000969447,0.001012183],"genre_scores_gemma":[0.9934369,0.0002495066,0.001517249,0.001997818,0.0005940678,0.0001492742,0.00007141478,0.00005198233,0.001931759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2393336,"threshold_uncertainty_score":0.8179328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01648737672001088,"score_gpt":0.256941070704351,"score_spread":0.2404536939843401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}